Human prostatic acid phosphatase

Structure, function and regulation

Sakthivel Muniyan, Nagendra K. Chaturvedi, Jennifer G. Dwyer, Chad A LaGrange, William G Chaney, Ming-Fong Lin

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Human prostatic acid phosphatase (PAcP) is a 100 kDa glycoprotein composed of two subunits. Recent advances demonstrate that cellular PAcP (cPAcP) functions as a protein tyrosine phosphatase by dephosphorylating ErbB-2/Neu/HER-2 at the phosphotyrosine residues in prostate cancer (PCa) cells, which results in reduced tumorigenicity. Further, the interaction of cPAcP and ErbB-2 regulates androgen sensitivity of PCa cells. Knockdown of cPAcP expression allows androgen-sensitive PCa cells to develop the castration-resistant phenotype, where cells proliferate under an androgen-reduced condition. Thus, cPAcP has a significant influence on PCa cell growth. Interestingly, promoter analysis suggests that PAcP expression can be regulated by NF-κB, via a novel binding sequence in an androgen-independent manner. Further understanding of PAcP function and regulation of expression will have a significant impact on understanding PCa progression and therapy.

Original languageEnglish (US)
Pages (from-to)10438-10464
Number of pages27
JournalInternational journal of molecular sciences
Volume14
Issue number5
DOIs
StatePublished - May 1 2013

Fingerprint

phosphatases
Phosphatases
Androgens
Prostatic Neoplasms
cancer
acids
Acids
Phosphotyrosine
Protein Tyrosine Phosphatases
cells
Cell growth
Glycoproteins
phenotype
tyrosine
Castration
progressions
Cells
therapy
prostatic acid phosphatase
proteins

Keywords

  • Epigenetic regulation
  • ErbB-2
  • Immunotherapy
  • Prostate cancer
  • Prostatic acid phosphatase
  • Protein tyrosine phosphatase
  • Tumor suppressor

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Human prostatic acid phosphatase : Structure, function and regulation. / Muniyan, Sakthivel; Chaturvedi, Nagendra K.; Dwyer, Jennifer G.; LaGrange, Chad A; Chaney, William G; Lin, Ming-Fong.

In: International journal of molecular sciences, Vol. 14, No. 5, 01.05.2013, p. 10438-10464.

Research output: Contribution to journalReview article

Muniyan, Sakthivel ; Chaturvedi, Nagendra K. ; Dwyer, Jennifer G. ; LaGrange, Chad A ; Chaney, William G ; Lin, Ming-Fong. / Human prostatic acid phosphatase : Structure, function and regulation. In: International journal of molecular sciences. 2013 ; Vol. 14, No. 5. pp. 10438-10464.
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