Human plasma inflammatory response during 5 days of exercise training in the heat

Walter S. Hailes, Dustin Slivka, John Cuddy, Brent C. Ruby

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The aim of the present investigation was to examine the response of 80 plasma inflammatory analytes during five days of exercise in a hot (38°C, 40% relative humidity) environment. 15 male participants (25±4yrs, 54±6mlkg-1min-1 VO2 max), with no heat exposure within the previous 3 weeks, were asked to cycle in a hot environment at 70% of their VO2 max workload until their terminal temperature was obtained, for 5 consecutive days. Terminal temperature was determined as the core temperature at volitional exhaustion or a core temperature of 39.5°C, whichever came first. Blood samples were collected pre- and post-exercise on day 1 and day 5. Pre-trial urine specific gravity and body weight was not different on day 1 and day 5. Exercise time and heart rate at terminal temperature did not change during the five days. Of the 52 plasma analytes that increased in concentration on day 1, only 30 demonstrated increased concentrations at terminal temperature on day 5. Resting concentrations of 18, both pro- (IL-12p40, IL-15) and anti-inflammatory (IL-1ra, IL-10, IL-13) analytes were elevated on day 5 compared to day 1. We conclude that individuals completing consecutive days of exercise in the heat, but not definitively attaining heat acclimation, have increased resting levels of many inflammatory analytes associated with heat illness, but also demonstrate a reduced inflammatory response to a subsequent bout of exercise in the heat.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalJournal of Thermal Biology
Volume36
Issue number5
DOIs
StatePublished - Jul 1 2011

Fingerprint

Plasma (human)
exercise
Hot Temperature
inflammation
Exercise
heat
Temperature
temperature
Interleukin-12 Subunit p40
Interleukin 1 Receptor Antagonist Protein
Plasmas
Interleukin-15
Specific Gravity
Interleukin-13
Acclimatization
interleukin-10
specific gravity
Humidity
Workload
Density (specific gravity)

Keywords

  • Acclimation
  • Cytokine
  • Exercise
  • Heat stroke
  • Human
  • Hyperthermia
  • Inflammation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Agricultural and Biological Sciences(all)
  • Developmental Biology

Cite this

Human plasma inflammatory response during 5 days of exercise training in the heat. / Hailes, Walter S.; Slivka, Dustin; Cuddy, John; Ruby, Brent C.

In: Journal of Thermal Biology, Vol. 36, No. 5, 01.07.2011, p. 277-282.

Research output: Contribution to journalArticle

Hailes, Walter S. ; Slivka, Dustin ; Cuddy, John ; Ruby, Brent C. / Human plasma inflammatory response during 5 days of exercise training in the heat. In: Journal of Thermal Biology. 2011 ; Vol. 36, No. 5. pp. 277-282.
@article{c1d6ba9dc0734a15b1b6c1d15bd9f4b6,
title = "Human plasma inflammatory response during 5 days of exercise training in the heat",
abstract = "The aim of the present investigation was to examine the response of 80 plasma inflammatory analytes during five days of exercise in a hot (38°C, 40{\%} relative humidity) environment. 15 male participants (25±4yrs, 54±6mlkg-1min-1 VO2 max), with no heat exposure within the previous 3 weeks, were asked to cycle in a hot environment at 70{\%} of their VO2 max workload until their terminal temperature was obtained, for 5 consecutive days. Terminal temperature was determined as the core temperature at volitional exhaustion or a core temperature of 39.5°C, whichever came first. Blood samples were collected pre- and post-exercise on day 1 and day 5. Pre-trial urine specific gravity and body weight was not different on day 1 and day 5. Exercise time and heart rate at terminal temperature did not change during the five days. Of the 52 plasma analytes that increased in concentration on day 1, only 30 demonstrated increased concentrations at terminal temperature on day 5. Resting concentrations of 18, both pro- (IL-12p40, IL-15) and anti-inflammatory (IL-1ra, IL-10, IL-13) analytes were elevated on day 5 compared to day 1. We conclude that individuals completing consecutive days of exercise in the heat, but not definitively attaining heat acclimation, have increased resting levels of many inflammatory analytes associated with heat illness, but also demonstrate a reduced inflammatory response to a subsequent bout of exercise in the heat.",
keywords = "Acclimation, Cytokine, Exercise, Heat stroke, Human, Hyperthermia, Inflammation",
author = "Hailes, {Walter S.} and Dustin Slivka and John Cuddy and Ruby, {Brent C.}",
year = "2011",
month = "7",
day = "1",
doi = "10.1016/j.jtherbio.2011.03.013",
language = "English (US)",
volume = "36",
pages = "277--282",
journal = "Journal of Thermal Biology",
issn = "0306-4565",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Human plasma inflammatory response during 5 days of exercise training in the heat

AU - Hailes, Walter S.

AU - Slivka, Dustin

AU - Cuddy, John

AU - Ruby, Brent C.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - The aim of the present investigation was to examine the response of 80 plasma inflammatory analytes during five days of exercise in a hot (38°C, 40% relative humidity) environment. 15 male participants (25±4yrs, 54±6mlkg-1min-1 VO2 max), with no heat exposure within the previous 3 weeks, were asked to cycle in a hot environment at 70% of their VO2 max workload until their terminal temperature was obtained, for 5 consecutive days. Terminal temperature was determined as the core temperature at volitional exhaustion or a core temperature of 39.5°C, whichever came first. Blood samples were collected pre- and post-exercise on day 1 and day 5. Pre-trial urine specific gravity and body weight was not different on day 1 and day 5. Exercise time and heart rate at terminal temperature did not change during the five days. Of the 52 plasma analytes that increased in concentration on day 1, only 30 demonstrated increased concentrations at terminal temperature on day 5. Resting concentrations of 18, both pro- (IL-12p40, IL-15) and anti-inflammatory (IL-1ra, IL-10, IL-13) analytes were elevated on day 5 compared to day 1. We conclude that individuals completing consecutive days of exercise in the heat, but not definitively attaining heat acclimation, have increased resting levels of many inflammatory analytes associated with heat illness, but also demonstrate a reduced inflammatory response to a subsequent bout of exercise in the heat.

AB - The aim of the present investigation was to examine the response of 80 plasma inflammatory analytes during five days of exercise in a hot (38°C, 40% relative humidity) environment. 15 male participants (25±4yrs, 54±6mlkg-1min-1 VO2 max), with no heat exposure within the previous 3 weeks, were asked to cycle in a hot environment at 70% of their VO2 max workload until their terminal temperature was obtained, for 5 consecutive days. Terminal temperature was determined as the core temperature at volitional exhaustion or a core temperature of 39.5°C, whichever came first. Blood samples were collected pre- and post-exercise on day 1 and day 5. Pre-trial urine specific gravity and body weight was not different on day 1 and day 5. Exercise time and heart rate at terminal temperature did not change during the five days. Of the 52 plasma analytes that increased in concentration on day 1, only 30 demonstrated increased concentrations at terminal temperature on day 5. Resting concentrations of 18, both pro- (IL-12p40, IL-15) and anti-inflammatory (IL-1ra, IL-10, IL-13) analytes were elevated on day 5 compared to day 1. We conclude that individuals completing consecutive days of exercise in the heat, but not definitively attaining heat acclimation, have increased resting levels of many inflammatory analytes associated with heat illness, but also demonstrate a reduced inflammatory response to a subsequent bout of exercise in the heat.

KW - Acclimation

KW - Cytokine

KW - Exercise

KW - Heat stroke

KW - Human

KW - Hyperthermia

KW - Inflammation

UR - http://www.scopus.com/inward/record.url?scp=79957451344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79957451344&partnerID=8YFLogxK

U2 - 10.1016/j.jtherbio.2011.03.013

DO - 10.1016/j.jtherbio.2011.03.013

M3 - Article

AN - SCOPUS:79957451344

VL - 36

SP - 277

EP - 282

JO - Journal of Thermal Biology

JF - Journal of Thermal Biology

SN - 0306-4565

IS - 5

ER -