Human immunodeficiency virus and hepatotropic viruses comorbidities as the inducers of liver injury progression

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Abstract

Hepatotropic viruses induced hepatitis progresses much faster and causes more liver- related health problems in people co-infected with human immunodeficiency virus (HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus (HBV) and hepatitis C virus (HCV) causes significant numbers of non-acquired immune deficiency syndrome (AIDS)-related deaths in coinfected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals (DAA) and antiretroviral therapy (ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV coinfected individuals.

Original languageEnglish (US)
Pages (from-to)398-410
Number of pages13
JournalWorld Journal of Gastroenterology
Volume25
Issue number4
DOIs
StatePublished - Jan 28 2019

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Comorbidity
HIV
Viruses
Liver
Hepatitis B virus
Wounds and Injuries
Hepacivirus
Virus Diseases
Liver Diseases
Coinfection
Hepatitis Viruses
Therapeutics
Life Expectancy
Natural History
Antiviral Agents
Disease Progression
Fibrosis
Health

Keywords

  • Fibrosis
  • Hepatitis B virus
  • Hepatitis C virus
  • Human immunodeficiency virus
  • Stiffness
  • Treatment

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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title = "Human immunodeficiency virus and hepatotropic viruses comorbidities as the inducers of liver injury progression",
abstract = "Hepatotropic viruses induced hepatitis progresses much faster and causes more liver- related health problems in people co-infected with human immunodeficiency virus (HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus (HBV) and hepatitis C virus (HCV) causes significant numbers of non-acquired immune deficiency syndrome (AIDS)-related deaths in coinfected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals (DAA) and antiretroviral therapy (ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV coinfected individuals.",
keywords = "Fibrosis, Hepatitis B virus, Hepatitis C virus, Human immunodeficiency virus, Stiffness, Treatment",
author = "Murali Ganesan and Poluektova, {Larisa Y.} and Kharbanda, {Kusum K.} and Osna, {Natalia A.}",
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AU - Ganesan, Murali

AU - Poluektova, Larisa Y.

AU - Kharbanda, Kusum K.

AU - Osna, Natalia A.

PY - 2019/1/28

Y1 - 2019/1/28

N2 - Hepatotropic viruses induced hepatitis progresses much faster and causes more liver- related health problems in people co-infected with human immunodeficiency virus (HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus (HBV) and hepatitis C virus (HCV) causes significant numbers of non-acquired immune deficiency syndrome (AIDS)-related deaths in coinfected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals (DAA) and antiretroviral therapy (ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV coinfected individuals.

AB - Hepatotropic viruses induced hepatitis progresses much faster and causes more liver- related health problems in people co-infected with human immunodeficiency virus (HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus (HBV) and hepatitis C virus (HCV) causes significant numbers of non-acquired immune deficiency syndrome (AIDS)-related deaths in coinfected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals (DAA) and antiretroviral therapy (ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV coinfected individuals.

KW - Fibrosis

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - Human immunodeficiency virus

KW - Stiffness

KW - Treatment

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