Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6

Kirsten B. Bibbins, Jen Yue Tsai, John Schimenti, Nora Sarvetnick, Huda Y. Zoghbi, Peter Goodfellow, Lee M. Silver

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Our laboratory has recently cloned and characterized two testes-expressed loci-the Tcp-10 gene family cluster and the D17Si11 gene-that map to the proximal portion of mouse chromosome 17. Human homologs of both loci have been identified and cloned. Somatic cell hybrid lines have been used to map the human homolog of D17Si11 to the short arm of chromosome 6 (p11-p21.1) along with homologs of other genes from the (Pim-1)-(Pgk-2) region of the mouse chromosome. The human TCP 10 locus maps to the long arm of chromosome 6 (q21-qter) along with homologs of other genes from the mouse chromosome 17 region between the centromere and Pim-1. The mapping of large portions of the mouse t haplotype to unlinked regions on human chromosome 6 rules out the possibility that a t-haplotype-like chromosome could exist in humans.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalGenomics
Volume5
Issue number1
DOIs
StatePublished - Jul 1989
Externally publishedYes

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Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 6
Testis
t-Complex Genome Region
Chromosomes
Genes
Centromere
Hybrid Cells
Human Chromosomes
Multigene Family
Haplotypes
Cell Line

ASJC Scopus subject areas

  • Genetics

Cite this

Bibbins, K. B., Tsai, J. Y., Schimenti, J., Sarvetnick, N., Zoghbi, H. Y., Goodfellow, P., & Silver, L. M. (1989). Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6. Genomics, 5(1), 139-143. https://doi.org/10.1016/0888-7543(89)90098-0

Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6. / Bibbins, Kirsten B.; Tsai, Jen Yue; Schimenti, John; Sarvetnick, Nora; Zoghbi, Huda Y.; Goodfellow, Peter; Silver, Lee M.

In: Genomics, Vol. 5, No. 1, 07.1989, p. 139-143.

Research output: Contribution to journalArticle

Bibbins, KB, Tsai, JY, Schimenti, J, Sarvetnick, N, Zoghbi, HY, Goodfellow, P & Silver, LM 1989, 'Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6', Genomics, vol. 5, no. 1, pp. 139-143. https://doi.org/10.1016/0888-7543(89)90098-0
Bibbins, Kirsten B. ; Tsai, Jen Yue ; Schimenti, John ; Sarvetnick, Nora ; Zoghbi, Huda Y. ; Goodfellow, Peter ; Silver, Lee M. / Human homologs of two testes-expressed loci on mouse chromosome 17 map to opposite arms of chromosome 6. In: Genomics. 1989 ; Vol. 5, No. 1. pp. 139-143.
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