Human Herpesvirus 8-Related Primary Effusion Lymphoma after Liver Transplantation

E. S. Christenson, B. Teply, V. Agrawal, P. Illei, A. Gurakar, J. A. Kanakry

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Primary effusion lymphoma is a rare subclass of non-Hodgkin lymphoma associated with human herpesvirus 8 infection and principally seen in human immunodeficiency virus-positive patients. We report on the case of a 72-year-old human immunodeficiency virus-negative male with a hepatic transplant 10 years prior, who presented with a symptomatic right-sided pleural effusion and was found to have primary effusion lymphoma by flow cytometric and cytopathologic examination. Immunohistochemistry of his lymphoma cells was positive for human herpesvirus 8. Both he and his donor had no identifiable risk factors for human herpesvirus 8 infection. The patient was intolerant of antiviral therapy and chemotherapy, dying 7 months after diagnosis. Posttransplant primary effusion lymphoma is exceedingly rare and carries a very poor prognosis. Individualized treatment strategies are necessary given the scant body of published literature with guidance based solely on case reports.

Original languageEnglish (US)
Pages (from-to)2762-2766
Number of pages5
JournalAmerican Journal of Transplantation
Volume15
Issue number10
DOIs
StatePublished - Oct 1 2015

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Keywords

  • Antibiotic: antiviral
  • cancer/malignancy/neoplasia: hematogenous/leukemia/lymphoma
  • complication: infectious
  • complication: malignant, infection and infectious agents
  • viral: human herpes virus 8 (HHV-8)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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