Human dermal fibroblasts in psychiatry research

S. Kálmán, K. A. Garbett, Z. Janka, K. Mirnics

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

In order to decipher the disease etiology, progression and treatment of multifactorial human brain diseases we utilize a host of different experimental models. Recently, patient-derived human dermal fibroblast (HDF) cultures have re-emerged as promising in vitro functional system for examining various cellular, molecular, metabolic and (patho)physiological states and traits of psychiatric disorders. HDF studies serve as a powerful complement to postmortem and animal studies, and often appear to be informative about the altered homeostasis in neural tissue. Studies of HDFs from patients with schizophrenia (SZ), depression, bipolar disorder (BD), autism, attention deficit and hyperactivity disorder and other psychiatric disorders have significantly advanced our understanding of these devastating diseases. These reports unequivocally prove that signal transduction, redox homeostasis, circadian rhythms and gene*environment (G*E) interactions are all amenable for assessment by the HDF model. Furthermore, the reported findings suggest that this underutilized patient biomaterial, combined with modern molecular biology techniques, may have both diagnostic and prognostic value, including prediction of response to therapeutic agents.

Original languageEnglish (US)
Pages (from-to)105-121
Number of pages17
JournalNeuroscience
Volume320
DOIs
StatePublished - Apr 21 2016

Fingerprint

Psychiatry
Fibroblasts
Skin
Research
Homeostasis
Gene-Environment Interaction
Brain Diseases
Biocompatible Materials
Attention Deficit Disorder with Hyperactivity
Autistic Disorder
Circadian Rhythm
Bipolar Disorder
Oxidation-Reduction
Disease Progression
Molecular Biology
Signal Transduction
Schizophrenia
Theoretical Models
Depression
Therapeutics

Keywords

  • Bipolar disorder
  • Dermal fibroblasts
  • Gene
  • In vitro model
  • Major depression
  • Schizophrenia
  • environment interaction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Human dermal fibroblasts in psychiatry research. / Kálmán, S.; Garbett, K. A.; Janka, Z.; Mirnics, K.

In: Neuroscience, Vol. 320, 21.04.2016, p. 105-121.

Research output: Contribution to journalReview article

Kálmán, S. ; Garbett, K. A. ; Janka, Z. ; Mirnics, K. / Human dermal fibroblasts in psychiatry research. In: Neuroscience. 2016 ; Vol. 320. pp. 105-121.
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