How to build a biofilm: a fungal perspective

Jill R. Blankenship, Aaron P. Mitchell

Research output: Contribution to journalReview article

322 Citations (Scopus)

Abstract

Biofilms are differentiated masses of microbes that form on surfaces and are surrounded by an extracellular matrix. Fungal biofilms, especially those of the pathogen Candida albicans, are a cause of infections associated with medical devices. Such infections are particularly serious because biofilm cells are relatively resistant to many common antifungal agents. Several in vitro models have been used to elucidate the developmental stages and processes required for C. albicans biofilm formation, and recent studies have begun to define biofilm genetic control. It is clear that cell-substrate and cell-cell interactions, hyphal differentiation and extracellular matrix production are key steps in biofilm development. Drug resistance is acquired early in biofilm formation, and appears to be governed by different mechanisms in early and late biofilms. Quorum sensing might be an important factor in dispersal of biofilm cells. The past two years have seen the emergence of several genomic strategies to uncover global events in biofilm formation and directed studies to understand more specific events, such as hyphal formation, in the biofilm setting.

Original languageEnglish (US)
Pages (from-to)588-594
Number of pages7
JournalCurrent Opinion in Microbiology
Volume9
Issue number6
DOIs
StatePublished - Dec 1 2006

Fingerprint

Biofilms
Candida albicans
Extracellular Matrix
Quorum Sensing
Antifungal Agents
Infection
Drug Resistance
Cell Communication
Equipment and Supplies

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

How to build a biofilm : a fungal perspective. / Blankenship, Jill R.; Mitchell, Aaron P.

In: Current Opinion in Microbiology, Vol. 9, No. 6, 01.12.2006, p. 588-594.

Research output: Contribution to journalReview article

Blankenship, Jill R. ; Mitchell, Aaron P. / How to build a biofilm : a fungal perspective. In: Current Opinion in Microbiology. 2006 ; Vol. 9, No. 6. pp. 588-594.
@article{6ebecfad6f294501ad783a6d4f989f8c,
title = "How to build a biofilm: a fungal perspective",
abstract = "Biofilms are differentiated masses of microbes that form on surfaces and are surrounded by an extracellular matrix. Fungal biofilms, especially those of the pathogen Candida albicans, are a cause of infections associated with medical devices. Such infections are particularly serious because biofilm cells are relatively resistant to many common antifungal agents. Several in vitro models have been used to elucidate the developmental stages and processes required for C. albicans biofilm formation, and recent studies have begun to define biofilm genetic control. It is clear that cell-substrate and cell-cell interactions, hyphal differentiation and extracellular matrix production are key steps in biofilm development. Drug resistance is acquired early in biofilm formation, and appears to be governed by different mechanisms in early and late biofilms. Quorum sensing might be an important factor in dispersal of biofilm cells. The past two years have seen the emergence of several genomic strategies to uncover global events in biofilm formation and directed studies to understand more specific events, such as hyphal formation, in the biofilm setting.",
author = "Blankenship, {Jill R.} and Mitchell, {Aaron P.}",
year = "2006",
month = "12",
day = "1",
doi = "10.1016/j.mib.2006.10.003",
language = "English (US)",
volume = "9",
pages = "588--594",
journal = "Current Opinion in Microbiology",
issn = "1369-5274",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - How to build a biofilm

T2 - a fungal perspective

AU - Blankenship, Jill R.

AU - Mitchell, Aaron P.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Biofilms are differentiated masses of microbes that form on surfaces and are surrounded by an extracellular matrix. Fungal biofilms, especially those of the pathogen Candida albicans, are a cause of infections associated with medical devices. Such infections are particularly serious because biofilm cells are relatively resistant to many common antifungal agents. Several in vitro models have been used to elucidate the developmental stages and processes required for C. albicans biofilm formation, and recent studies have begun to define biofilm genetic control. It is clear that cell-substrate and cell-cell interactions, hyphal differentiation and extracellular matrix production are key steps in biofilm development. Drug resistance is acquired early in biofilm formation, and appears to be governed by different mechanisms in early and late biofilms. Quorum sensing might be an important factor in dispersal of biofilm cells. The past two years have seen the emergence of several genomic strategies to uncover global events in biofilm formation and directed studies to understand more specific events, such as hyphal formation, in the biofilm setting.

AB - Biofilms are differentiated masses of microbes that form on surfaces and are surrounded by an extracellular matrix. Fungal biofilms, especially those of the pathogen Candida albicans, are a cause of infections associated with medical devices. Such infections are particularly serious because biofilm cells are relatively resistant to many common antifungal agents. Several in vitro models have been used to elucidate the developmental stages and processes required for C. albicans biofilm formation, and recent studies have begun to define biofilm genetic control. It is clear that cell-substrate and cell-cell interactions, hyphal differentiation and extracellular matrix production are key steps in biofilm development. Drug resistance is acquired early in biofilm formation, and appears to be governed by different mechanisms in early and late biofilms. Quorum sensing might be an important factor in dispersal of biofilm cells. The past two years have seen the emergence of several genomic strategies to uncover global events in biofilm formation and directed studies to understand more specific events, such as hyphal formation, in the biofilm setting.

UR - http://www.scopus.com/inward/record.url?scp=33751235557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751235557&partnerID=8YFLogxK

U2 - 10.1016/j.mib.2006.10.003

DO - 10.1016/j.mib.2006.10.003

M3 - Review article

C2 - 17055772

AN - SCOPUS:33751235557

VL - 9

SP - 588

EP - 594

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

IS - 6

ER -