How effective is endoscopic therapy in the treatment of patients with early esophageal cancer?

Shailender Singh, Prateek Sharma

Research output: Contribution to journalComment/debate

4 Citations (Scopus)

Abstract

Endoscopic therapy is increasingly used to treat high-grade dysplasia and/or early mucosal adenocarcinoma in patients with Barrett's esophagus. However, no randomized controlled trials have directly compared the efficacy of endoscopic therapy and traditional surgical approaches. This commentary discusses the findings of a retrospective, population-based study by Das et al. that demonstrates the effectiveness of endoscopic resection and/or endoscopic ablation in the treatment of early esophageal cancer. This study used data from the Surveillance Epidemiology and End Results database of the National Cancer Institute to compare cancer-free survival in patients with early esophageal cancer who were either treated with endoscopic therapy (n = 99) or surgical resection (n = 643). Analysis using a Cox proportional hazards model did not reveal a difference in esophageal cancer-specific mortality between the two groups. These results, therefore, support the use of endoscopic therapy in the treatment of early-stage esophageal cancer.

Original languageEnglish (US)
Pages (from-to)70-71
Number of pages2
JournalNature Clinical Practice Gastroenterology and Hepatology
Volume6
Issue number2
DOIs
StatePublished - Jan 1 2009

Fingerprint

Esophageal Neoplasms
Therapeutics
Barrett Esophagus
National Cancer Institute (U.S.)
Proportional Hazards Models
Epidemiology
Adenocarcinoma
Randomized Controlled Trials
Databases
Survival
Mortality
Population
Neoplasms

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

How effective is endoscopic therapy in the treatment of patients with early esophageal cancer? / Singh, Shailender; Sharma, Prateek.

In: Nature Clinical Practice Gastroenterology and Hepatology, Vol. 6, No. 2, 01.01.2009, p. 70-71.

Research output: Contribution to journalComment/debate

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