Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis

Nanda Kishore Routhu, Siddappa N. Byrareddy

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurological disorders such as microcephaly and Guillain-Barré syndrome in susceptible individuals. The mode of ZIKV entry into specific cell types such as: epidermal keratinocytes, fibroblasts, immature dendritic cells (iDCs), and stem-cell-derived human neural progenitors has been determined through its major surface envelope glycoprotein. It has been known that oligosaccharides that are covalently linked to viral envelope proteins are crucial in defining host-virus interactions. However, the role of sugars/glycans in exploiting host-immune mechanisms and aiding receptor-mediated virus entry is not well defined. Therefore, this review focuses on host-pathogen interactions to better understand ZIKV pathogenesis.

Original languageEnglish (US)
Pages (from-to)219-232
Number of pages14
JournalJournal of Neuroimmune Pharmacology
Volume12
Issue number2
DOIs
StatePublished - Jun 1 2017

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Keywords

  • Host-virus interaction
  • Immunity
  • Neuropathogenesis
  • Virus glycosylation
  • Zika virus

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

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