Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis

Nanda Kishore Routhu, Siddappa Nagadenahalli Byrareddy

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurological disorders such as microcephaly and Guillain-Barré syndrome in susceptible individuals. The mode of ZIKV entry into specific cell types such as: epidermal keratinocytes, fibroblasts, immature dendritic cells (iDCs), and stem-cell-derived human neural progenitors has been determined through its major surface envelope glycoprotein. It has been known that oligosaccharides that are covalently linked to viral envelope proteins are crucial in defining host-virus interactions. However, the role of sugars/glycans in exploiting host-immune mechanisms and aiding receptor-mediated virus entry is not well defined. Therefore, this review focuses on host-pathogen interactions to better understand ZIKV pathogenesis.

Original languageEnglish (US)
Pages (from-to)219-232
Number of pages14
JournalJournal of Neuroimmune Pharmacology
Volume12
Issue number2
DOIs
StatePublished - Jun 1 2017

Fingerprint

Virus Internalization
Aedes
Viruses
Viral Envelope Proteins
Host-Pathogen Interactions
Microcephaly
Membrane Glycoproteins
Nervous System Diseases
Culicidae
Oligosaccharides
Keratinocytes
Dendritic Cells
Polysaccharides
Stem Cells
Fibroblasts
Zika Virus

Keywords

  • Host-virus interaction
  • Immunity
  • Neuropathogenesis
  • Virus glycosylation
  • Zika virus

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis. / Routhu, Nanda Kishore; Byrareddy, Siddappa Nagadenahalli.

In: Journal of Neuroimmune Pharmacology, Vol. 12, No. 2, 01.06.2017, p. 219-232.

Research output: Contribution to journalReview article

@article{3847ce6ff578421b93e5b396744baee0,
title = "Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis",
abstract = "The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurological disorders such as microcephaly and Guillain-Barr{\'e} syndrome in susceptible individuals. The mode of ZIKV entry into specific cell types such as: epidermal keratinocytes, fibroblasts, immature dendritic cells (iDCs), and stem-cell-derived human neural progenitors has been determined through its major surface envelope glycoprotein. It has been known that oligosaccharides that are covalently linked to viral envelope proteins are crucial in defining host-virus interactions. However, the role of sugars/glycans in exploiting host-immune mechanisms and aiding receptor-mediated virus entry is not well defined. Therefore, this review focuses on host-pathogen interactions to better understand ZIKV pathogenesis.",
keywords = "Host-virus interaction, Immunity, Neuropathogenesis, Virus glycosylation, Zika virus",
author = "Routhu, {Nanda Kishore} and Byrareddy, {Siddappa Nagadenahalli}",
year = "2017",
month = "6",
day = "1",
doi = "10.1007/s11481-017-9736-7",
language = "English (US)",
volume = "12",
pages = "219--232",
journal = "Journal of NeuroImmune Pharmacology",
issn = "1557-1890",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Host-Virus Interaction of ZIKA Virus in Modulating Disease Pathogenesis

AU - Routhu, Nanda Kishore

AU - Byrareddy, Siddappa Nagadenahalli

PY - 2017/6/1

Y1 - 2017/6/1

N2 - The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurological disorders such as microcephaly and Guillain-Barré syndrome in susceptible individuals. The mode of ZIKV entry into specific cell types such as: epidermal keratinocytes, fibroblasts, immature dendritic cells (iDCs), and stem-cell-derived human neural progenitors has been determined through its major surface envelope glycoprotein. It has been known that oligosaccharides that are covalently linked to viral envelope proteins are crucial in defining host-virus interactions. However, the role of sugars/glycans in exploiting host-immune mechanisms and aiding receptor-mediated virus entry is not well defined. Therefore, this review focuses on host-pathogen interactions to better understand ZIKV pathogenesis.

AB - The Zika virus (ZIKV) is a newly emerging pathogen that has resulted in a worldwide epidemic. It primarily spreads either through infected Aedes aegypti or Aedes albopictus mosquitos leading to severe neurological disorders such as microcephaly and Guillain-Barré syndrome in susceptible individuals. The mode of ZIKV entry into specific cell types such as: epidermal keratinocytes, fibroblasts, immature dendritic cells (iDCs), and stem-cell-derived human neural progenitors has been determined through its major surface envelope glycoprotein. It has been known that oligosaccharides that are covalently linked to viral envelope proteins are crucial in defining host-virus interactions. However, the role of sugars/glycans in exploiting host-immune mechanisms and aiding receptor-mediated virus entry is not well defined. Therefore, this review focuses on host-pathogen interactions to better understand ZIKV pathogenesis.

KW - Host-virus interaction

KW - Immunity

KW - Neuropathogenesis

KW - Virus glycosylation

KW - Zika virus

UR - http://www.scopus.com/inward/record.url?scp=85016104361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016104361&partnerID=8YFLogxK

U2 - 10.1007/s11481-017-9736-7

DO - 10.1007/s11481-017-9736-7

M3 - Review article

C2 - 28349242

AN - SCOPUS:85016104361

VL - 12

SP - 219

EP - 232

JO - Journal of NeuroImmune Pharmacology

JF - Journal of NeuroImmune Pharmacology

SN - 1557-1890

IS - 2

ER -