Abstract

The lung is protected by an array of interacting defense mechanisms. These include mechanical defenses that filter and remove particulates from the inhaled air as well as mechanisms to capture and remove particulates that penetrate into the lung as well as chemical and cellular defenses that can kill invading microorganisms. Optimal lung defense requires coordinated action of these various defenses. However, whereas failure of any defense mechanism increases the risk of infection, the various mechanisms provide, at least to a certain extent, redundant protection. As a result, many individuals with compromise of a single defense mechanism may not become clinically ill. Syndromes characterized by chronic infection of the lower respiratory tract are therefore associated with several defects in respiratory tract defense. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish (US)
Pages (from-to)7-13
Number of pages7
JournalSeminars in Respiratory Infections
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2000

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Lung
Respiratory Tract Infections
Respiratory System
Air
Infection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Microbiology (medical)

Cite this

Host defenses and pathogenesis. / Rennard, Stephen I.; Romberger, Debra.

In: Seminars in Respiratory Infections, Vol. 15, No. 1, 01.01.2000, p. 7-13.

Research output: Contribution to journalReview article

Rennard, Stephen I. ; Romberger, Debra. / Host defenses and pathogenesis. In: Seminars in Respiratory Infections. 2000 ; Vol. 15, No. 1. pp. 7-13.
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