Host defense antimicrobial peptides as antibiotics: design and application strategies

Biswajit Mishra, Scott Reiling, D. Zarena, Guangshun Wang

Research output: Contribution to journalReview article

75 Citations (Scopus)

Abstract

This review deals with the design and application strategies of new antibiotics based on naturally occurring antimicrobial peptides (AMPs). The initial candidate can be designed based on three-dimensional structure or selected from a library of peptides from natural or laboratory sources followed by optimization via structure-activity relationship studies. There are also advanced application strategies such as induction of AMP expression from host cells by various factors (e.g., metals, amino acids, vitamin D and sunlight), the use of engineered probiotic bacteria to deliver peptides, the design of prodrug and peptide conjugates to improve specific targeting. In addition, combined uses of newly developed AMPs with existing antimicrobial agents may provide a practical avenue for effective management of antibiotic-resistant bacteria (superbugs), including biofilms. Finally, we highlight AMPs already in use or under clinical trials.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalCurrent Opinion in Chemical Biology
Volume38
DOIs
StatePublished - Jun 1 2017

Fingerprint

Anti-Bacterial Agents
Peptides
Bacteria
Peptide Library
Sunlight
Prodrugs
Probiotics
Biofilms
Structure-Activity Relationship
Anti-Infective Agents
Vitamin D
Metals
Clinical Trials
Amino Acids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Host defense antimicrobial peptides as antibiotics : design and application strategies. / Mishra, Biswajit; Reiling, Scott; Zarena, D.; Wang, Guangshun.

In: Current Opinion in Chemical Biology, Vol. 38, 01.06.2017, p. 87-96.

Research output: Contribution to journalReview article

@article{8dd188faa6b44cd987a3b03977428a6b,
title = "Host defense antimicrobial peptides as antibiotics: design and application strategies",
abstract = "This review deals with the design and application strategies of new antibiotics based on naturally occurring antimicrobial peptides (AMPs). The initial candidate can be designed based on three-dimensional structure or selected from a library of peptides from natural or laboratory sources followed by optimization via structure-activity relationship studies. There are also advanced application strategies such as induction of AMP expression from host cells by various factors (e.g., metals, amino acids, vitamin D and sunlight), the use of engineered probiotic bacteria to deliver peptides, the design of prodrug and peptide conjugates to improve specific targeting. In addition, combined uses of newly developed AMPs with existing antimicrobial agents may provide a practical avenue for effective management of antibiotic-resistant bacteria (superbugs), including biofilms. Finally, we highlight AMPs already in use or under clinical trials.",
author = "Biswajit Mishra and Scott Reiling and D. Zarena and Guangshun Wang",
year = "2017",
month = "6",
day = "1",
doi = "10.1016/j.cbpa.2017.03.014",
language = "English (US)",
volume = "38",
pages = "87--96",
journal = "Current Opinion in Chemical Biology",
issn = "1367-5931",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Host defense antimicrobial peptides as antibiotics

T2 - design and application strategies

AU - Mishra, Biswajit

AU - Reiling, Scott

AU - Zarena, D.

AU - Wang, Guangshun

PY - 2017/6/1

Y1 - 2017/6/1

N2 - This review deals with the design and application strategies of new antibiotics based on naturally occurring antimicrobial peptides (AMPs). The initial candidate can be designed based on three-dimensional structure or selected from a library of peptides from natural or laboratory sources followed by optimization via structure-activity relationship studies. There are also advanced application strategies such as induction of AMP expression from host cells by various factors (e.g., metals, amino acids, vitamin D and sunlight), the use of engineered probiotic bacteria to deliver peptides, the design of prodrug and peptide conjugates to improve specific targeting. In addition, combined uses of newly developed AMPs with existing antimicrobial agents may provide a practical avenue for effective management of antibiotic-resistant bacteria (superbugs), including biofilms. Finally, we highlight AMPs already in use or under clinical trials.

AB - This review deals with the design and application strategies of new antibiotics based on naturally occurring antimicrobial peptides (AMPs). The initial candidate can be designed based on three-dimensional structure or selected from a library of peptides from natural or laboratory sources followed by optimization via structure-activity relationship studies. There are also advanced application strategies such as induction of AMP expression from host cells by various factors (e.g., metals, amino acids, vitamin D and sunlight), the use of engineered probiotic bacteria to deliver peptides, the design of prodrug and peptide conjugates to improve specific targeting. In addition, combined uses of newly developed AMPs with existing antimicrobial agents may provide a practical avenue for effective management of antibiotic-resistant bacteria (superbugs), including biofilms. Finally, we highlight AMPs already in use or under clinical trials.

UR - http://www.scopus.com/inward/record.url?scp=85017159441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017159441&partnerID=8YFLogxK

U2 - 10.1016/j.cbpa.2017.03.014

DO - 10.1016/j.cbpa.2017.03.014

M3 - Review article

C2 - 28399505

AN - SCOPUS:85017159441

VL - 38

SP - 87

EP - 96

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

SN - 1367-5931

ER -