Hospitalized cardiovascular events in patients with diabetic macular edema

Bao Anh Nguyen-Khoa, Earl L. Goehring, Winifred Werther, Anne E. Fung, Diana V Do, Rajendra S. Apte, Judith K. Jones

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Microvascular and macrovascular complications in diabetes stem from chronic hyperglycemia and are thought to have overlapping pathophysiology. The aim of this study was to investigate the incidence rate of hospitalized myocardial infarctions (MI) and cerebrovascular accidents (CVA) in patients with diabetic macular edema (DME) compared with diabetic patients without retinal diseases. Methods: This was a retrospective cohort study of a commercially insured population in an administrative claims database. DME subjects (n = 3519) and diabetes controls without retinal disease (n = 10557) were matched by age and gender. Healthcare claims were analyzed for the study period from 1 January 2002 to 31 December 2005. Incidence and adjusted rate ratios of hospitalized MI and CVA events were then calculated.Results: The adjusted rate ratio for MI was 2.50 (95% CI: 1.83-3.41, p<0.001) for DME versus diabetes controls. Predictors of MI events were heart disease, history of acute MI, and prior use of antiplatelet or anticoagulant drugs. The adjusted rate ratio for CVA was 1.98 (95% CI: 1.39-2.83, p<0.001) for DME versus diabetes controls. Predictors of CVA events were cardiac arrhythmia, Charlson comorbidity scores, history of CVA, hyperlipidemia, and other cerebrovascular diseases. Conclusion: Event rates of MI or CVA were higher in patients with DME than in diabetes controls. This study is one of few with sufficient sample size to accurately estimate the relationship between DME and cardiovascular outcomes.

Original languageEnglish (US)
Article number11
JournalBMC Ophthalmology
Volume12
Issue number1
DOIs
StatePublished - May 31 2012

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Macular Edema
Stroke
Myocardial Infarction
Retinal Diseases
Cerebrovascular Disorders
Platelet Aggregation Inhibitors
Incidence
Diabetes Complications
Hyperlipidemias
Hyperglycemia
Sample Size
Anticoagulants
Comorbidity
Cardiac Arrhythmias
Heart Diseases
Cohort Studies
Retrospective Studies
Databases
Delivery of Health Care
Population

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Nguyen-Khoa, B. A., Goehring, E. L., Werther, W., Fung, A. E., Do, D. V., Apte, R. S., & Jones, J. K. (2012). Hospitalized cardiovascular events in patients with diabetic macular edema. BMC Ophthalmology, 12(1), [11]. https://doi.org/10.1186/1471-2415-12-11

Hospitalized cardiovascular events in patients with diabetic macular edema. / Nguyen-Khoa, Bao Anh; Goehring, Earl L.; Werther, Winifred; Fung, Anne E.; Do, Diana V; Apte, Rajendra S.; Jones, Judith K.

In: BMC Ophthalmology, Vol. 12, No. 1, 11, 31.05.2012.

Research output: Contribution to journalArticle

Nguyen-Khoa, BA, Goehring, EL, Werther, W, Fung, AE, Do, DV, Apte, RS & Jones, JK 2012, 'Hospitalized cardiovascular events in patients with diabetic macular edema', BMC Ophthalmology, vol. 12, no. 1, 11. https://doi.org/10.1186/1471-2415-12-11
Nguyen-Khoa BA, Goehring EL, Werther W, Fung AE, Do DV, Apte RS et al. Hospitalized cardiovascular events in patients with diabetic macular edema. BMC Ophthalmology. 2012 May 31;12(1). 11. https://doi.org/10.1186/1471-2415-12-11
Nguyen-Khoa, Bao Anh ; Goehring, Earl L. ; Werther, Winifred ; Fung, Anne E. ; Do, Diana V ; Apte, Rajendra S. ; Jones, Judith K. / Hospitalized cardiovascular events in patients with diabetic macular edema. In: BMC Ophthalmology. 2012 ; Vol. 12, No. 1.
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