Hormonal control of implantation: A possible role of lysosomal function in the embryo-uterus interaction

Jayasree Sengupta, S. K. Roy, S. K. Manchanda

Research output: Contribution to journalArticle

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Abstract

Using rat, mouse and rabbit animal systems we have investigated a possible role for lysosomal enzymes in the embryo attachment reaction. Specific histochemical methods were used to study the activity patterns of lysosomal enzymes, acid phosphatase, leucylnaphthylamidase and non-specific esterase, as well as lipid content in blastocysts collected from rats and mice just prior to nidation. In all three species, the cellular distribution and activity patterns of these enzymes in uterine regions bearing implanting blastocysts were shown to differ considerably from those in non-implant bearing uterine sites. From results obtained with oestrogen antagonists, nafoxidine and CI-628 citrate, we suggest that local oestrogen action, probably arising from the blastocyst, is essential for the initiation of increased cellular permeability and associated changes in lysosomal enzyme patterns necessary for the formation of the implantation chamber in the rat and mouse and for the embryo attachment reaction in the rabbit.

Original languageEnglish (US)
Pages (from-to)729-744
Number of pages16
JournalJournal of Steroid Biochemistry
Volume11
Issue number1 PART 3
DOIs
StatePublished - Jul 1979

Fingerprint

Uterus
Blastocyst
Bearings (structural)
Embryonic Structures
Rats
Enzymes
Nitromifene
Nafoxidine
Rabbits
Estrogen Antagonists
Carboxylesterase
Acid Phosphatase
Citric Acid
Permeability
Estrogens
Animals
Lipids

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Hormonal control of implantation : A possible role of lysosomal function in the embryo-uterus interaction. / Sengupta, Jayasree; Roy, S. K.; Manchanda, S. K.

In: Journal of Steroid Biochemistry, Vol. 11, No. 1 PART 3, 07.1979, p. 729-744.

Research output: Contribution to journalArticle

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