Homozygosity for the Minallele of Apc results in disruption of mouse development prior to gastrulation

Amy Rapaich Moser, Alex R. Shoemaker, Camille S. Connelly, Linda Clipson, Karen A Gould, Cindy Luongo, William F. Dove, Pamela H. Siggers, Richard L. Gardner

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Mutation of the APC (adenomatous polyposis coli) gene is an early event in colon tumor development in humans. Mice carrying Min (multiple intestinal neoplasia), a mutant allele of Apc, develop intestinal and mammary tumors as adults. To study the role of the Apc gene in development, we have investigated the phenotype of embryos homozygous for ApcMin (Min). Development of the primitive ectoderm fails prior to gastrulation in homozygous Min embryos. By midgestation, the presumed homozygotes consist of a mass of trophoblast giant cells with an additional cluster of much smaller embryonic cells. These results indicate that functional Apc is required for normal growth of inner cell mass derivatives. ©1995 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)422-433
Number of pages12
JournalDevelopmental Dynamics
Volume203
Issue number4
DOIs
StatePublished - Jan 1 1995

Fingerprint

Gastrulation
Neoplasms
Embryonic Structures
APC Genes
Ectoderm
Homozygote
Trophoblasts
Human Development
Giant Cells
Colon
Alleles
Breast Neoplasms
Phenotype
Mutation
Growth
Genes

Keywords

  • Apc
  • Conceptus
  • Mouse development
  • Postimplantation mutant
  • Primitive ectoderm
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Moser, A. R., Shoemaker, A. R., Connelly, C. S., Clipson, L., Gould, K. A., Luongo, C., ... Gardner, R. L. (1995). Homozygosity for the Minallele of Apc results in disruption of mouse development prior to gastrulation. Developmental Dynamics, 203(4), 422-433. https://doi.org/10.1002/aja.1002030405

Homozygosity for the Minallele of Apc results in disruption of mouse development prior to gastrulation. / Moser, Amy Rapaich; Shoemaker, Alex R.; Connelly, Camille S.; Clipson, Linda; Gould, Karen A; Luongo, Cindy; Dove, William F.; Siggers, Pamela H.; Gardner, Richard L.

In: Developmental Dynamics, Vol. 203, No. 4, 01.01.1995, p. 422-433.

Research output: Contribution to journalArticle

Moser, AR, Shoemaker, AR, Connelly, CS, Clipson, L, Gould, KA, Luongo, C, Dove, WF, Siggers, PH & Gardner, RL 1995, 'Homozygosity for the Minallele of Apc results in disruption of mouse development prior to gastrulation', Developmental Dynamics, vol. 203, no. 4, pp. 422-433. https://doi.org/10.1002/aja.1002030405
Moser, Amy Rapaich ; Shoemaker, Alex R. ; Connelly, Camille S. ; Clipson, Linda ; Gould, Karen A ; Luongo, Cindy ; Dove, William F. ; Siggers, Pamela H. ; Gardner, Richard L. / Homozygosity for the Minallele of Apc results in disruption of mouse development prior to gastrulation. In: Developmental Dynamics. 1995 ; Vol. 203, No. 4. pp. 422-433.
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