HLA-DR Allele frequencies in mexican mestizos with autoimmune liver diseases including overlap syndromes

Sergio Zepeda-Gomez, Aldo Montao-Loza, Juan Carlos Zapata-Colindres, Francisco Paz, Marco Olivera-Martinez, Alberto Lpez-Reyes, Julio Granados, Gilberto Vargas-Alarcn

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Autoimmune liver diseases are sometimes difficult to differentiate from hepatic overlap syndromes (OS). The objective of this study was to use polymorphic genetic markers to better distinguish clinical heterogeneity in autoimmune liver disease. Since autoimmunity is the result of autoantibody production we studied HLA-DR alleles in 20 patients with autoimmune hepatitis (AIH), 16 with primary biliary cirrhosis (PBC), 10 with OS, and in 99 ethnically matched healthy individuals. Patients with OS had significantly higher alkaline phosphatase and total bilirubin levels than patients with AIH. OS patients had a higher prevalence of positive antinuclear antibodies and a higher AIH score than patients with PBC. Patients with OS also had higher total immunoglobulin levels (IgG isotype) as compared to patients with PBC. We found in PBC patients a higher gene frequency of HLA-DR4 and DR1 as compared to healthy controls (p 0.03, OR 2.2 and p 0.004, OR 4.3, respectively) and to OS patients (p 0.01, OR 6.8, and p 0.004, OR 10.0, respectively). On the other hand, the gene frequency of HLADR5 was significantly decreased in the total group of patients as compared to healthy controls suggesting a protective role of this allele for developing autoimmune liver disease.

Original languageEnglish (US)
Pages (from-to)276-283
Number of pages8
JournalImmunological Investigations
Volume38
Issue number3-4
DOIs
StatePublished - Nov 9 2009

Fingerprint

HLA-DR Antigens
Gene Frequency
Autoimmune Diseases
Liver Diseases
Biliary Liver Cirrhosis
Autoimmune Hepatitis
HLA-DR1 Antigen
Alleles
HLA-DR4 Antigen
Antinuclear Antibodies
Autoimmunity
Genetic Markers
Bilirubin
Autoantibodies
Alkaline Phosphatase
Immunoglobulins
Immunoglobulin G
Liver

Keywords

  • Autoimmune hepatitis
  • Overlap syndrome
  • Primary biliary cirrhosis

ASJC Scopus subject areas

  • Immunology

Cite this

Zepeda-Gomez, S., Montao-Loza, A., Zapata-Colindres, J. C., Paz, F., Olivera-Martinez, M., Lpez-Reyes, A., ... Vargas-Alarcn, G. (2009). HLA-DR Allele frequencies in mexican mestizos with autoimmune liver diseases including overlap syndromes. Immunological Investigations, 38(3-4), 276-283. https://doi.org/10.1080/08820130902846282

HLA-DR Allele frequencies in mexican mestizos with autoimmune liver diseases including overlap syndromes. / Zepeda-Gomez, Sergio; Montao-Loza, Aldo; Zapata-Colindres, Juan Carlos; Paz, Francisco; Olivera-Martinez, Marco; Lpez-Reyes, Alberto; Granados, Julio; Vargas-Alarcn, Gilberto.

In: Immunological Investigations, Vol. 38, No. 3-4, 09.11.2009, p. 276-283.

Research output: Contribution to journalArticle

Zepeda-Gomez, S, Montao-Loza, A, Zapata-Colindres, JC, Paz, F, Olivera-Martinez, M, Lpez-Reyes, A, Granados, J & Vargas-Alarcn, G 2009, 'HLA-DR Allele frequencies in mexican mestizos with autoimmune liver diseases including overlap syndromes', Immunological Investigations, vol. 38, no. 3-4, pp. 276-283. https://doi.org/10.1080/08820130902846282
Zepeda-Gomez, Sergio ; Montao-Loza, Aldo ; Zapata-Colindres, Juan Carlos ; Paz, Francisco ; Olivera-Martinez, Marco ; Lpez-Reyes, Alberto ; Granados, Julio ; Vargas-Alarcn, Gilberto. / HLA-DR Allele frequencies in mexican mestizos with autoimmune liver diseases including overlap syndromes. In: Immunological Investigations. 2009 ; Vol. 38, No. 3-4. pp. 276-283.
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