HLA class I polymorphism has a dual impact on ligand binding and chaperone interaction

William H. Hildebrand, Heth R. Turnquist, Kiley R. Prilliman, Heather D. Hickman, Erin L. Schenk, Mary M. McIlhaney, Joyce C Solheim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

This article will describe coordinated analyses of how amino acid substitutions in the HLA class I antigen binding groove modify chaperone interaction and peptide ligand presentation. By parallel testing of ligand presentation and chaperone interaction with a series of natural HLA-B subtypes, this study has discovered that position 116 of the HLA-B15 class I heavy chain is pivotal in both peptide selection and control of interaction between the assembly complex and the class I heavy chain. Correlated with these qualitative differences in peptide selection and chaperone association are quantitative differences in the expression levels of the HLA molecules at the cell surface. These parallel studies, therefore, demonstrate that particular HLA class I polymorphisms can simultaneously influence ligand presentation and interaction with intracellular chaperones.

Original languageEnglish (US)
Pages (from-to)248-255
Number of pages8
JournalHuman Immunology
Volume63
Issue number4
DOIs
StatePublished - Jan 1 2002

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Ligands
Peptides
HLA-B15 Antigen
Histocompatibility Antigens Class I
HLA-B Antigens
Amino Acid Substitution
HLA Antigens

Keywords

  • Antigen presentation
  • HLA
  • MHC
  • Peptide
  • Tapasin

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Hildebrand, W. H., Turnquist, H. R., Prilliman, K. R., Hickman, H. D., Schenk, E. L., McIlhaney, M. M., & Solheim, J. C. (2002). HLA class I polymorphism has a dual impact on ligand binding and chaperone interaction. Human Immunology, 63(4), 248-255. https://doi.org/10.1016/S0198-8859(02)00364-6

HLA class I polymorphism has a dual impact on ligand binding and chaperone interaction. / Hildebrand, William H.; Turnquist, Heth R.; Prilliman, Kiley R.; Hickman, Heather D.; Schenk, Erin L.; McIlhaney, Mary M.; Solheim, Joyce C.

In: Human Immunology, Vol. 63, No. 4, 01.01.2002, p. 248-255.

Research output: Contribution to journalArticle

Hildebrand, WH, Turnquist, HR, Prilliman, KR, Hickman, HD, Schenk, EL, McIlhaney, MM & Solheim, JC 2002, 'HLA class I polymorphism has a dual impact on ligand binding and chaperone interaction', Human Immunology, vol. 63, no. 4, pp. 248-255. https://doi.org/10.1016/S0198-8859(02)00364-6
Hildebrand WH, Turnquist HR, Prilliman KR, Hickman HD, Schenk EL, McIlhaney MM et al. HLA class I polymorphism has a dual impact on ligand binding and chaperone interaction. Human Immunology. 2002 Jan 1;63(4):248-255. https://doi.org/10.1016/S0198-8859(02)00364-6
Hildebrand, William H. ; Turnquist, Heth R. ; Prilliman, Kiley R. ; Hickman, Heather D. ; Schenk, Erin L. ; McIlhaney, Mary M. ; Solheim, Joyce C. / HLA class I polymorphism has a dual impact on ligand binding and chaperone interaction. In: Human Immunology. 2002 ; Vol. 63, No. 4. pp. 248-255.
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