HIV replication and persistence in human gastrointestinal cells cultured in vitro

M. P. Moyer, H. E. Gendelman

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Epithelial and submucosal mesenchymal (SM) cells from human small intestine and colon could be directly infected by several strains of the human immunodeficiency virus (HIV). Macrophage-derived virus strains were more potent than the HTLVIIIB prototype strain. Persistent release of virus over several months implies that the human gastrointestinal tract may serve as a site for primary infection and as a reservoir for the virus. Furthermore, HIV infection of SM cells may be an in vitro model of Kaposi's sarcoma.

Original languageEnglish (US)
Pages (from-to)499-504
Number of pages6
JournalJournal of Leukocyte Biology
Volume49
Issue number5
DOIs
StatePublished - Jan 1 1991

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Keywords

  • Acquired immune deficiency syndrome (AIDS)
  • Cell culture models
  • Kaposi's sarcoma
  • Virus latency
  • Virus persistence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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