HIV-associated neurocognitive disorders in sub-Saharan Africa: A pilot study in Cameroon

Georgette D. Kanmogne, Callixte T. Kuate, Lucette A. Cysique, Julius Y. Fonsah, Sabine Eta, Roland Doh, Dora M. Njamnshi, Emilienne Nchindap, Donald R. Franklin, Ronald J. Ellis, John A. McCutchan, Fidele Binam, Dora Mbanya, Robert K. Heaton, Alfred K. Njamnshi

Research output: Contribution to journalArticle

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Abstract

Background: The disease burden of human immunodeficiency virus (HIV) - acquired immunodeficiency syndrome (AIDS) is highest in sub-Saharan Africa but there are few studies on the associated neurocognitive disorders in this region. The objectives of this study were to determine whether Western neuropsychological (NP) methods are appropriate for use in Cameroon, and to evaluate cognitive function in a sample of HIV-infected adults.Methods: We used a battery of 19 NP measures in a cross-sectional study with 44 HIV+ adults and 44 demographically matched HIV- controls, to explore the validity of these NP measures in Cameroon, and evaluate the effect of viral infection on seven cognitive ability domains.Results: In this pilot study, the global mean z-score on the NP battery showed worse overall cognition in the HIV+ individuals. Significantly lower performance was seen in the HIV+ sample on tests of executive function, speed of information processing, working memory, and psychomotor speed. HIV+ participants with AIDS performed worse than those with less advanced HIV disease.Conclusions: Similar to findings in Western cohorts, our results in Cameroon suggest that HIV infection, particularly in advanced stages, is associated with worse performance on standardized, Western neurocognitive tests. The tests used here appear to be promising for studying NeuroAIDS in sub-Saharan Africa.

Original languageEnglish (US)
Article number60
JournalBMC Neurology
Volume10
DOIs
StatePublished - Jul 13 2010

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Cameroon
Africa South of the Sahara
HIV
Virus Diseases
Cognition
Acquired Immunodeficiency Syndrome
Neurocognitive Disorders
Aptitude
Executive Function
Automatic Data Processing
Short-Term Memory
Cross-Sectional Studies

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Kanmogne, G. D., Kuate, C. T., Cysique, L. A., Fonsah, J. Y., Eta, S., Doh, R., ... Njamnshi, A. K. (2010). HIV-associated neurocognitive disorders in sub-Saharan Africa: A pilot study in Cameroon. BMC Neurology, 10, [60]. https://doi.org/10.1186/1471-2377-10-60

HIV-associated neurocognitive disorders in sub-Saharan Africa : A pilot study in Cameroon. / Kanmogne, Georgette D.; Kuate, Callixte T.; Cysique, Lucette A.; Fonsah, Julius Y.; Eta, Sabine; Doh, Roland; Njamnshi, Dora M.; Nchindap, Emilienne; Franklin, Donald R.; Ellis, Ronald J.; McCutchan, John A.; Binam, Fidele; Mbanya, Dora; Heaton, Robert K.; Njamnshi, Alfred K.

In: BMC Neurology, Vol. 10, 60, 13.07.2010.

Research output: Contribution to journalArticle

Kanmogne, GD, Kuate, CT, Cysique, LA, Fonsah, JY, Eta, S, Doh, R, Njamnshi, DM, Nchindap, E, Franklin, DR, Ellis, RJ, McCutchan, JA, Binam, F, Mbanya, D, Heaton, RK & Njamnshi, AK 2010, 'HIV-associated neurocognitive disorders in sub-Saharan Africa: A pilot study in Cameroon', BMC Neurology, vol. 10, 60. https://doi.org/10.1186/1471-2377-10-60
Kanmogne, Georgette D. ; Kuate, Callixte T. ; Cysique, Lucette A. ; Fonsah, Julius Y. ; Eta, Sabine ; Doh, Roland ; Njamnshi, Dora M. ; Nchindap, Emilienne ; Franklin, Donald R. ; Ellis, Ronald J. ; McCutchan, John A. ; Binam, Fidele ; Mbanya, Dora ; Heaton, Robert K. ; Njamnshi, Alfred K. / HIV-associated neurocognitive disorders in sub-Saharan Africa : A pilot study in Cameroon. In: BMC Neurology. 2010 ; Vol. 10.
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abstract = "Background: The disease burden of human immunodeficiency virus (HIV) - acquired immunodeficiency syndrome (AIDS) is highest in sub-Saharan Africa but there are few studies on the associated neurocognitive disorders in this region. The objectives of this study were to determine whether Western neuropsychological (NP) methods are appropriate for use in Cameroon, and to evaluate cognitive function in a sample of HIV-infected adults.Methods: We used a battery of 19 NP measures in a cross-sectional study with 44 HIV+ adults and 44 demographically matched HIV- controls, to explore the validity of these NP measures in Cameroon, and evaluate the effect of viral infection on seven cognitive ability domains.Results: In this pilot study, the global mean z-score on the NP battery showed worse overall cognition in the HIV+ individuals. Significantly lower performance was seen in the HIV+ sample on tests of executive function, speed of information processing, working memory, and psychomotor speed. HIV+ participants with AIDS performed worse than those with less advanced HIV disease.Conclusions: Similar to findings in Western cohorts, our results in Cameroon suggest that HIV infection, particularly in advanced stages, is associated with worse performance on standardized, Western neurocognitive tests. The tests used here appear to be promising for studying NeuroAIDS in sub-Saharan Africa.",
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AU - Cysique, Lucette A.

AU - Fonsah, Julius Y.

AU - Eta, Sabine

AU - Doh, Roland

AU - Njamnshi, Dora M.

AU - Nchindap, Emilienne

AU - Franklin, Donald R.

AU - Ellis, Ronald J.

AU - McCutchan, John A.

AU - Binam, Fidele

AU - Mbanya, Dora

AU - Heaton, Robert K.

AU - Njamnshi, Alfred K.

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N2 - Background: The disease burden of human immunodeficiency virus (HIV) - acquired immunodeficiency syndrome (AIDS) is highest in sub-Saharan Africa but there are few studies on the associated neurocognitive disorders in this region. The objectives of this study were to determine whether Western neuropsychological (NP) methods are appropriate for use in Cameroon, and to evaluate cognitive function in a sample of HIV-infected adults.Methods: We used a battery of 19 NP measures in a cross-sectional study with 44 HIV+ adults and 44 demographically matched HIV- controls, to explore the validity of these NP measures in Cameroon, and evaluate the effect of viral infection on seven cognitive ability domains.Results: In this pilot study, the global mean z-score on the NP battery showed worse overall cognition in the HIV+ individuals. Significantly lower performance was seen in the HIV+ sample on tests of executive function, speed of information processing, working memory, and psychomotor speed. HIV+ participants with AIDS performed worse than those with less advanced HIV disease.Conclusions: Similar to findings in Western cohorts, our results in Cameroon suggest that HIV infection, particularly in advanced stages, is associated with worse performance on standardized, Western neurocognitive tests. The tests used here appear to be promising for studying NeuroAIDS in sub-Saharan Africa.

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