HIV and cocaine interplay in HIV-associated neurocognitive disorders

Honghong Yao, Crystal Bethel-Brown, Shilpa J Buch

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

While antiretrovirals are becoming the gold standard in HIV care and are effective in suppressing viremia, the relative inability of these drugs to penetrate the blood-brain barrier, the latency of HIV in the tissues, and the increased life span of individuals on therapy often lead to complications of HIV in the central nervous system (CNS) termed as HIV-associated neurocognitive disorders (HAND). Among the individuals inflicted with HAND, almost 30 % have a history of substance abuse. Among the commonly abused drugs, cocaine is the most widely used and has emerged as a key contributor to the seroprevalence and progression of HIV infection. Both epidemiological and laboratory-based studies demonstrate that cocaine promotes HIV replication and has multifaceted deleterious effects on the various cells of the CNS resulting in a disrupted blood-brain barrier, enhanced glial activation, and neurotoxicity. Effects of cocaine alone or in combination with HIV proteins lead to augmented neuropathogenesis. This review summarizes current understanding of the diverse effects of cocaine on the various cells of the CNS and how the drug synergizes with HIV and HIV proteins to exacerbate neurotoxicity.

Original languageEnglish (US)
Title of host publicationNeuroinflammation and Neurodegeneration
PublisherSpringer New York
Pages431-442
Number of pages12
ISBN (Electronic)9781493910717
ISBN (Print)1493910701, 9781493910700
DOIs
StatePublished - Apr 1 2014

Fingerprint

Cocaine
HIV
Human Immunodeficiency Virus Proteins
Blood-Brain Barrier
Central Nervous System
Central Nervous System Agents
Viremia
Seroepidemiologic Studies
Neurocognitive Disorders
Neuroglia
Pharmaceutical Preparations
HIV Infections
Substance-Related Disorders

Keywords

  • AIDS
  • CNS
  • Cocaine
  • Glial cell
  • HIV
  • HIV-1-associated neurocognitive disorders
  • Non-opioid receptor

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Yao, H., Bethel-Brown, C., & Buch, S. J. (2014). HIV and cocaine interplay in HIV-associated neurocognitive disorders. In Neuroinflammation and Neurodegeneration (pp. 431-442). Springer New York. https://doi.org/10.1007/978-1-4939-1071-7_20

HIV and cocaine interplay in HIV-associated neurocognitive disorders. / Yao, Honghong; Bethel-Brown, Crystal; Buch, Shilpa J.

Neuroinflammation and Neurodegeneration. Springer New York, 2014. p. 431-442.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yao, H, Bethel-Brown, C & Buch, SJ 2014, HIV and cocaine interplay in HIV-associated neurocognitive disorders. in Neuroinflammation and Neurodegeneration. Springer New York, pp. 431-442. https://doi.org/10.1007/978-1-4939-1071-7_20
Yao H, Bethel-Brown C, Buch SJ. HIV and cocaine interplay in HIV-associated neurocognitive disorders. In Neuroinflammation and Neurodegeneration. Springer New York. 2014. p. 431-442 https://doi.org/10.1007/978-1-4939-1071-7_20
Yao, Honghong ; Bethel-Brown, Crystal ; Buch, Shilpa J. / HIV and cocaine interplay in HIV-associated neurocognitive disorders. Neuroinflammation and Neurodegeneration. Springer New York, 2014. pp. 431-442
@inbook{1c4a3b2ec0a14052b628b6d4b85c45de,
title = "HIV and cocaine interplay in HIV-associated neurocognitive disorders",
abstract = "While antiretrovirals are becoming the gold standard in HIV care and are effective in suppressing viremia, the relative inability of these drugs to penetrate the blood-brain barrier, the latency of HIV in the tissues, and the increased life span of individuals on therapy often lead to complications of HIV in the central nervous system (CNS) termed as HIV-associated neurocognitive disorders (HAND). Among the individuals inflicted with HAND, almost 30 {\%} have a history of substance abuse. Among the commonly abused drugs, cocaine is the most widely used and has emerged as a key contributor to the seroprevalence and progression of HIV infection. Both epidemiological and laboratory-based studies demonstrate that cocaine promotes HIV replication and has multifaceted deleterious effects on the various cells of the CNS resulting in a disrupted blood-brain barrier, enhanced glial activation, and neurotoxicity. Effects of cocaine alone or in combination with HIV proteins lead to augmented neuropathogenesis. This review summarizes current understanding of the diverse effects of cocaine on the various cells of the CNS and how the drug synergizes with HIV and HIV proteins to exacerbate neurotoxicity.",
keywords = "AIDS, CNS, Cocaine, Glial cell, HIV, HIV-1-associated neurocognitive disorders, Non-opioid receptor",
author = "Honghong Yao and Crystal Bethel-Brown and Buch, {Shilpa J}",
year = "2014",
month = "4",
day = "1",
doi = "10.1007/978-1-4939-1071-7_20",
language = "English (US)",
isbn = "1493910701",
pages = "431--442",
booktitle = "Neuroinflammation and Neurodegeneration",
publisher = "Springer New York",

}

TY - CHAP

T1 - HIV and cocaine interplay in HIV-associated neurocognitive disorders

AU - Yao, Honghong

AU - Bethel-Brown, Crystal

AU - Buch, Shilpa J

PY - 2014/4/1

Y1 - 2014/4/1

N2 - While antiretrovirals are becoming the gold standard in HIV care and are effective in suppressing viremia, the relative inability of these drugs to penetrate the blood-brain barrier, the latency of HIV in the tissues, and the increased life span of individuals on therapy often lead to complications of HIV in the central nervous system (CNS) termed as HIV-associated neurocognitive disorders (HAND). Among the individuals inflicted with HAND, almost 30 % have a history of substance abuse. Among the commonly abused drugs, cocaine is the most widely used and has emerged as a key contributor to the seroprevalence and progression of HIV infection. Both epidemiological and laboratory-based studies demonstrate that cocaine promotes HIV replication and has multifaceted deleterious effects on the various cells of the CNS resulting in a disrupted blood-brain barrier, enhanced glial activation, and neurotoxicity. Effects of cocaine alone or in combination with HIV proteins lead to augmented neuropathogenesis. This review summarizes current understanding of the diverse effects of cocaine on the various cells of the CNS and how the drug synergizes with HIV and HIV proteins to exacerbate neurotoxicity.

AB - While antiretrovirals are becoming the gold standard in HIV care and are effective in suppressing viremia, the relative inability of these drugs to penetrate the blood-brain barrier, the latency of HIV in the tissues, and the increased life span of individuals on therapy often lead to complications of HIV in the central nervous system (CNS) termed as HIV-associated neurocognitive disorders (HAND). Among the individuals inflicted with HAND, almost 30 % have a history of substance abuse. Among the commonly abused drugs, cocaine is the most widely used and has emerged as a key contributor to the seroprevalence and progression of HIV infection. Both epidemiological and laboratory-based studies demonstrate that cocaine promotes HIV replication and has multifaceted deleterious effects on the various cells of the CNS resulting in a disrupted blood-brain barrier, enhanced glial activation, and neurotoxicity. Effects of cocaine alone or in combination with HIV proteins lead to augmented neuropathogenesis. This review summarizes current understanding of the diverse effects of cocaine on the various cells of the CNS and how the drug synergizes with HIV and HIV proteins to exacerbate neurotoxicity.

KW - AIDS

KW - CNS

KW - Cocaine

KW - Glial cell

KW - HIV

KW - HIV-1-associated neurocognitive disorders

KW - Non-opioid receptor

UR - http://www.scopus.com/inward/record.url?scp=84929849179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929849179&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-1071-7_20

DO - 10.1007/978-1-4939-1071-7_20

M3 - Chapter

AN - SCOPUS:84929849179

SN - 1493910701

SN - 9781493910700

SP - 431

EP - 442

BT - Neuroinflammation and Neurodegeneration

PB - Springer New York

ER -