HIV-1 Tat-mediated neurotoxicity in retinal cells

Nivedita Chatterjee, Shannon Callen, Gail M. Seigel, Shilpa J Buch

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The current study was aimed at investigating the effect of HIV-1 protein Tat on the retinal neurosensory cell line R28. Exposure of Tat resulted in induction of pro-inflammatory mediators such as CXCL10 and TNF-α in addition to the activation marker GFAP in these cells. Conditioned media from Tat-treated R28 cells was able to induce monocyte migration, an effect that was blocked by CXCR3 antagonist. Complementary studies in the HIV-1 Tat-transgenic mice, showed a complete absence of the nuclear layer and the outer photoreceptor segments of the retina with a concomitant increase in glial activation. These findings lend support to the observation in post-HAART era of increased incidence of immune response-mediated retinal degeneration. These findings have direct relevance to diseases such as immune response uveitis and patients recovering from CMV retinitis.

Original languageEnglish (US)
Pages (from-to)399-408
Number of pages10
JournalJournal of Neuroimmune Pharmacology
Volume6
Issue number3
DOIs
Publication statusPublished - Sep 1 2011

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Keywords

  • Chemokine
  • HIV
  • Retina

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

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