Histone H3 phosphorylation

Universal code or lineage specific dialects?

Heriberto D Cerutti, J. Armando Casas-Mallano

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Post-translational modifications of histones modulate the functional landscape of chromatin and impinge on many DNA-mediated processes. Phosphorylation of histone H3 plays a role in the regulation of gene expression and in chromosome condensation/segregation. Certain evolutionarily conserved residues on histone H3, namely Thr3, Ser10, Thr11 and Ser28, are phosphorylated during interphase or mitosis in both metazoa and plants. However, many of the kinases involved in these events appear to have evolved independently in different lineages. Likewise, the mechanistic function of specific phosphorylated amino acids, although poorly understood, also seems to differ among eukaryotes. Moreover, some modifications, such as phosphorylation of histone H3 Ser10, appear to have both a positive and a negative connotation and only become meaningful in combination with other histone marks within a particular chromatin context. Thus, a detailed understanding of the influence of histone H3 phosphorylation on biological processes may require learning organismal dialects of the histone code.

Original languageEnglish (US)
Pages (from-to)71-75
Number of pages5
JournalEpigenetics
Volume4
Issue number2
DOIs
StatePublished - Feb 16 2009

Fingerprint

Histones
Phosphorylation
Histone Code
Chromatin
Biological Phenomena
Chromosome Segregation
Interphase
Gene Expression Regulation
Post Translational Protein Processing
Eukaryota
Mitosis
Phosphotransferases
Learning
Amino Acids
DNA

Keywords

  • Epigenetics
  • Gene silencing
  • Histone code
  • Histone phosphorylation
  • Phosphoacetylation
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

Cite this

Histone H3 phosphorylation : Universal code or lineage specific dialects? / Cerutti, Heriberto D; Casas-Mallano, J. Armando.

In: Epigenetics, Vol. 4, No. 2, 16.02.2009, p. 71-75.

Research output: Contribution to journalArticle

Cerutti, Heriberto D ; Casas-Mallano, J. Armando. / Histone H3 phosphorylation : Universal code or lineage specific dialects?. In: Epigenetics. 2009 ; Vol. 4, No. 2. pp. 71-75.
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