Histologic grade does not predict prognosis in optimally treated, advanced‐stage nodular sclerosing Hodgkin's disease

Aneal S. Masih, Dennis D. Weisenburger, Julie M. Vose, Martin A. Bast, James O. Armitage

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Abstract

Forty‐two patients with advanced‐stage nodular sclerosing Hodgkin's disease (NSHD) were treated uniformly with combination chemotherapy and radiation therapy at the University of Nebraska Medical Center between 1982 and 1987. The cases were subclassified into low‐grade (13 cases) and high‐grade (29 cases) categories using the British National Lymphoma Investigation (BNLI) histologic criteria. After a median follow‐up interval of 48 months, no significant differences with regard to the complete remission rate (100% versus 90%), remission durability (85% versus 96%), or predicted 4‐year actuarial survival (92% versus 86%) were observed between the two groups, respectively. It was concluded that the BNLI grading scheme for NSHD does not predict the clinical outcome of patients with advanced‐stage NSHD who receive optimal therapy.

Original languageEnglish (US)
Pages (from-to)228-232
Number of pages5
JournalCancer
Volume69
Issue number1
DOIs
StatePublished - Jan 1 1992

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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