Highly controlled coating of strontium-doped hydroxyapatite on electrospun poly(ɛ-caprolactone) fibers

Lin Weng, Matthew J Teusink, Franklin D. Shuler, Vivi Parecki, Jingwei Xie

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Electrospun fibers show great potential as scaffolds for bone tissue engineering due to their architectural biomimicry to the extracellular matrix (ECM). Cation substitution of strontium for calcium in hydroxyapatite (HAp) positively influences the mechanism of bone remodeling including enhancing bone regeneration and reducing bone resorption. The objective of this study was to attach strontium-doped HAp (SrHAp) to electrospun poly(ɛ-caprolactone) (PCL) fibers for creation of novel composite scaffolds that can not only mimic the architecture and composition of ECM but also affect bone remodeling favorably. We demonstrated for the first time the highly controlled SrHAp coatings on electrospun PCL fibers. We showed the reproducible manufacturing of composite fiber scaffolds with controllable thickness, composition, and morphology of SrHAp coatings. We further showed that the released strontium and calcium cations from coatings could reach effective concentrations within 1 day and endure more than 28 days. Additionally, the Young's modulus of the SrHAp-coated PCL fibers was up to around six times higher than that of raw fibers dependent on the coating thickness and composition. Together, this novel class of composite fiber scaffolds may hold great promise for bone regeneration.

Original languageEnglish (US)
Pages (from-to)753-763
Number of pages11
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume105
Issue number4
DOIs
StatePublished - May 1 2017

Fingerprint

Strontium
Durapatite
Hydroxyapatite
Bone
Coatings
Fibers
Scaffolds
Cations
Calcium
Composite materials
Positive ions
Chemical analysis
Bioelectric potentials
Scaffolds (biology)
polycaprolactone
Tissue engineering
Substitution reactions
Elastic moduli

Keywords

  • coating
  • electrospinning
  • hydroxyapatite
  • poly(ɛ-caprolactone) fibers
  • strontium

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Cite this

Highly controlled coating of strontium-doped hydroxyapatite on electrospun poly(ɛ-caprolactone) fibers. / Weng, Lin; Teusink, Matthew J; Shuler, Franklin D.; Parecki, Vivi; Xie, Jingwei.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 105, No. 4, 01.05.2017, p. 753-763.

Research output: Contribution to journalArticle

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