Higher vaginal pH in Trichomonas vaginalis infection with intermediate Nugent score in reproductive-age women—a hospital-based cross-sectional study in Odisha, India

Padmalaya Das, Tapoja Swain, Jyoti Ranjan Mohanty, Shalini Sinha, Bijay Padhi, Belen Torondel, Oliver Cumming, Bijaya Panda, Arati Nayak, Pinaki Panigrahi

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Abstract

A close association between Trichomonas vaginalis (TV) infection and bacterial vaginosis (BV) has been reported. Some other studies have found association is stronger with intermediate Nugent score than BV. Most studies have used wet mount microscopy, a relatively insensitive method, to detect TV infection. We wanted to study the association of TV infection with BV and with intermediate Nugent score. We undertook a cross-sectional hospital-based study of 1110 non-pregnant women from Odisha state, India, aged between 18 and 45 years, collecting vaginal swabs for diagnosis of BV by Nugent score (NS) criteria and TV by PCR analysis. TV infection was found in 13.3% of women with intermediate Nugent score (NS 4–6) and 13.6% with BV (NS 7–10). Before adjustment, TV infection was associated with BV, intermediate Nugent, vaginal pH ≥ 4.5, and age group between 26 and 35 years. Multivariate analysis confirmed that TV infection was more likely to have raised vaginal pH, either BV or intermediate Nugent. Proportion of TV cases increased sequentially with the increase in Nugent score up to NS 6, after which a decline was observed. Vaginal pH was higher in the TV-infected group than the uninfected group in women with intermediate Nugent, but no difference was noticed in women with BV. TV infection was equally prevalent in women with intermediate Nugent as well as BV. In the intermediate Nugent group women, TV infection was found only when vaginal pH was raised, indicating a crucial role of vaginal pH in determining TV infection.

Original languageEnglish (US)
Pages (from-to)2735-2742
Number of pages8
JournalParasitology research
Volume117
Issue number9
DOIs
StatePublished - Sep 1 2018

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Keywords

  • Bacterial vaginosis
  • Non-pregnant woman
  • Nugent score
  • Trichomonas vaginalis
  • Vaginal pH

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)
  • Insect Science
  • Infectious Diseases

Cite this

Das, P., Swain, T., Mohanty, J. R., Sinha, S., Padhi, B., Torondel, B., Cumming, O., Panda, B., Nayak, A., & Panigrahi, P. (2018). Higher vaginal pH in Trichomonas vaginalis infection with intermediate Nugent score in reproductive-age women—a hospital-based cross-sectional study in Odisha, India. Parasitology research, 117(9), 2735-2742. https://doi.org/10.1007/s00436-018-5962-z