High seroprevalence of human herpesvirus 8 and herpes simplex virus 2 infections in men who have sex with men in Shanghai, China

Zhenqiu Liu, Qiwen Fang, Jialu Zuo, Jun Wang, Yue Chen, Veenu Minhas, Charles Wood, Na He, Tiejun Zhang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Men who have sex with men (MSM) are an important risk group for human immunodeficiency virus (HIV) and at high-risk of herpesvirus infection. However, limited information on epidemiologic patterns of HHV8 and HSV2 among MSM is available in mainland China. A cross-sectional study of 486 participants was performed in Shanghai, China from January 2013 to December 2014 to explore epidemiologic features of HHV8 and HSV2 among MSM. Serum samples were collected and tested for HHV8 by immunofluoresence assay and HSV2 antibodies by ELISA. Logistic regression analysis was conducted to determine the risk factors of HHV8 and HSV2 infections, respectively. The overall seroprevalence was 23.0% for HHV8 infection and 22.4% for HSV2 infection. HHV8 seropositivity was significantly associated with being a money boy (odds ratio (OR) = 1.64; 95%CI: 1.04–2.58), having a steady sex partner (OR = 0.52; 95%CI: 0.31–0.87), having ever had anal sex with men (OR = 2.05; 95%CI: 1.09–3.86), and being HSV2 positive (OR = 2.14; 95%CI: 1.22–3.76). HSV2 seropositivity was significantly associate with being positive for HIV (OR = 2.12; 95%CI: 1.01–4.42), syphilis (OR = 1.98; 95%CI: 1.12–3.52), HHV8 (OR = 2.17; 95%CI: 1.24–3.83), and was marginally associated with being a money boy (OR = 1. 61; 95%CI: 0.97–2.86), and having ever had unprotected casual sex (OR = 1. 72; 95%CI: 0.99–2.99). HHV8 and HSV2 infections are common in Chinese MSM. It is important to implement programs for preventing herpes virus infection among MSM, particularly high-risk groups such as money buys. And protected sexual intercourse should be propagated. J. Med. Virol. 89:887–894, 2017.

Original languageEnglish (US)
Pages (from-to)887-894
Number of pages8
JournalJournal of Medical Virology
Volume89
Issue number5
DOIs
StatePublished - May 1 2017

Fingerprint

Human Herpesvirus 8
Human Herpesvirus 2
Seroepidemiologic Studies
Virus Diseases
China
Odds Ratio
Infection
HIV
Unsafe Sex
Herpesviridae Infections
Coitus
Sex Ratio
Syphilis
Sexual Behavior
Cross-Sectional Studies
Logistic Models
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Antibodies

Keywords

  • China
  • HSV2
  • KSHV
  • MSM

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

High seroprevalence of human herpesvirus 8 and herpes simplex virus 2 infections in men who have sex with men in Shanghai, China. / Liu, Zhenqiu; Fang, Qiwen; Zuo, Jialu; Wang, Jun; Chen, Yue; Minhas, Veenu; Wood, Charles; He, Na; Zhang, Tiejun.

In: Journal of Medical Virology, Vol. 89, No. 5, 01.05.2017, p. 887-894.

Research output: Contribution to journalArticle

Liu, Zhenqiu ; Fang, Qiwen ; Zuo, Jialu ; Wang, Jun ; Chen, Yue ; Minhas, Veenu ; Wood, Charles ; He, Na ; Zhang, Tiejun. / High seroprevalence of human herpesvirus 8 and herpes simplex virus 2 infections in men who have sex with men in Shanghai, China. In: Journal of Medical Virology. 2017 ; Vol. 89, No. 5. pp. 887-894.
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abstract = "Men who have sex with men (MSM) are an important risk group for human immunodeficiency virus (HIV) and at high-risk of herpesvirus infection. However, limited information on epidemiologic patterns of HHV8 and HSV2 among MSM is available in mainland China. A cross-sectional study of 486 participants was performed in Shanghai, China from January 2013 to December 2014 to explore epidemiologic features of HHV8 and HSV2 among MSM. Serum samples were collected and tested for HHV8 by immunofluoresence assay and HSV2 antibodies by ELISA. Logistic regression analysis was conducted to determine the risk factors of HHV8 and HSV2 infections, respectively. The overall seroprevalence was 23.0{\%} for HHV8 infection and 22.4{\%} for HSV2 infection. HHV8 seropositivity was significantly associated with being a money boy (odds ratio (OR) = 1.64; 95{\%}CI: 1.04–2.58), having a steady sex partner (OR = 0.52; 95{\%}CI: 0.31–0.87), having ever had anal sex with men (OR = 2.05; 95{\%}CI: 1.09–3.86), and being HSV2 positive (OR = 2.14; 95{\%}CI: 1.22–3.76). HSV2 seropositivity was significantly associate with being positive for HIV (OR = 2.12; 95{\%}CI: 1.01–4.42), syphilis (OR = 1.98; 95{\%}CI: 1.12–3.52), HHV8 (OR = 2.17; 95{\%}CI: 1.24–3.83), and was marginally associated with being a money boy (OR = 1. 61; 95{\%}CI: 0.97–2.86), and having ever had unprotected casual sex (OR = 1. 72; 95{\%}CI: 0.99–2.99). HHV8 and HSV2 infections are common in Chinese MSM. It is important to implement programs for preventing herpes virus infection among MSM, particularly high-risk groups such as money buys. And protected sexual intercourse should be propagated. J. Med. Virol. 89:887–894, 2017.",
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