Abstract

To investigate the possibility that a hypercoagulable state develops during autologous bone marrow transplantation (BMT), we measured levels of circulating natural anticoagulants and fibrinolytic proteins before and weekly during the hospital course of 18 patients undergoing autologous BMT for Hodgkin's and non-Hodgkin's lymphoma. Patients received either weekly (standard dose group) or daily (high dose group) vitamin K supplements with their total parenteral nutrition. By day 14 there had been a significant drop in protein C activity (mean of 95% of normal to 52%), protein C antigen (mean of 105% of normal to 70%), and antithrombin 3 activity (111% of normal to 83%), and an increase in fibrinogen (471-621mg/dl) and tissue plasminogen activator (6.9-13.8ng/ml). No changes were seen in free or total protein S, plasminogen activator inhibitor, prothrombin time or partial thromboplastin time. The decreases in protein C and antithrombin 3 persisted through day 28 after transplantation. The drop in protein C correlated strongly with decrease in serum albumin, suggesting impaired synthesis of these proteins by the liver. No differences were seen in any of these parameters between the standard and high dose groups. Deficiencies in anticoagulant proteins antithrombin 3 and protein C and a rise in fibrinogen without a concomitant improvement in fibrinolytic variables create a potentially hypercoagulable state which may contribute to the thrombotic complications of autologous BMT.

Original languageEnglish (US)
Pages (from-to)497-502
Number of pages6
JournalBone marrow transplantation
Volume8
Issue number6
StatePublished - Dec 1 1991

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Antithrombin Proteins
Protein C Deficiency
Autologous Transplantation
Protein C
Bone Marrow Transplantation
Lymphoma
Antithrombins
Fibrinogen
Plasminogen Inactivators
Partial Thromboplastin Time
Vitamin K
Total Parenteral Nutrition
Protein S
Prothrombin Time
Tissue Plasminogen Activator
Hodgkin Disease
Serum Albumin
Non-Hodgkin's Lymphoma
Anticoagulants
Proteins

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

High frequency of antithrombin 3 and protein C deficiency following autologous bone marrow transplantation for lymphoma. / Gordon, Bruce Geoffrey; Haire, W.; Kessinger, A.; Duggan, M.; Armitage, James Olen.

In: Bone marrow transplantation, Vol. 8, No. 6, 01.12.1991, p. 497-502.

Research output: Contribution to journalArticle

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T1 - High frequency of antithrombin 3 and protein C deficiency following autologous bone marrow transplantation for lymphoma

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AU - Haire, W.

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AU - Armitage, James Olen

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