High dose therapy and autologous marrow transplantation as salvage treatment for patients with diffuse large cell lymphoma

James Olen Armitage, Sundar Jagannath, Gary Spitzer, Philip Jay Bierman, Anne Kessinger, Pradeep Kumar, Fernando Cabanillas, Axel Zander, Lijda Vellekoop, Karel A. Dicke

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35 Scopus citations


Twenty-nine patients with diffuse large cell lymphoma who failed traditional chemotherapy were treated with high dose chemotherapy with or without total body irradiation followed by infusion of cryopreserved autologous marrow. Complete response was achieved in 11 29 patients (38%), partial response in 13 29 patients (45%) and 5 29 patients (17%) had no response. Six complete responders remain well and free of disease for 5+, 6+, 9+, 10+, 18+ and 25+ months, 3 relapsed at 2, 3 and 8 months after marrow infusion, and 2 died from infectious complications. Complete response was seen more frequently with the absence of bulky tumor (70 vs 21%, P = 0.03), a total body irradiation containing regimen (52 vs 0%, P = 0.03), a history of complete remission with initial chemotherapy (55% vs. 9%, P = 0.03), and a performance status ≥ 80 (56 vs 15%, P = 0.06). High dose therapy had a high response rate (83%) in resistant diffuse large cell lymphoma and yielded durable complete responses in a minority of these patients.

Original languageEnglish (US)
Pages (from-to)871-877
Number of pages7
JournalEuropean Journal of Cancer and Clinical Oncology
Issue number7
Publication statusPublished - Jul 1986


ASJC Scopus subject areas

  • Oncology

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