High-dose cyclophosphamide, carmustine, and etoposide and autologous bone marrow transplantation for relapsed Hodgkin's disease

S. Jagannath, K. A. Dicke, J. O. Armitage, F. F. Cabanillas, L. J. Horwitz, L. Vellekoop, A. R. Zander, G. Spitzer

Research output: Contribution to journalArticle

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Abstract

Thirty patients with relapsed Hodgkin's disease were treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) and autologous bone marrow transplantation. The median age of the patients was 28 years, and 18 were male. More than half had extranodal sites of relapse and constitutional symptoms. Most had been heavily pretreated with multiple salvage chemotherapy regimens and radiotherapy. At the time of transplantation, 23 patients were having progressive disease despite salvage chemotherapy. High-dose CBV chemotherapy induced complete responses in 15 patients and partial responses in 10 patients. Eleven patients are still in complete remission, 1 of whom has had an unmaintained remission for more than 44 months. Toxicity was moderate; all patients had severe myelosuppression requiring supportive therapy, and 1 patient failed to reconstitute her bone marrow. High-dose CBV chemotherapy and autologous bone marrow rescue proved to be effective as salvage therapy for a select group of heavily pretreated patients with relapsed Hodgkin's disease.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalAnnals of internal medicine
Volume104
Issue number2
DOIs
StatePublished - Jan 1 1986

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Carmustine
Autologous Transplantation
Etoposide
Bone Marrow Transplantation
Hodgkin Disease
Cyclophosphamide
Drug Therapy
Bone Marrow
Salvage Therapy
Radiotherapy
Transplantation
Recurrence

ASJC Scopus subject areas

  • Internal Medicine

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High-dose cyclophosphamide, carmustine, and etoposide and autologous bone marrow transplantation for relapsed Hodgkin's disease. / Jagannath, S.; Dicke, K. A.; Armitage, J. O.; Cabanillas, F. F.; Horwitz, L. J.; Vellekoop, L.; Zander, A. R.; Spitzer, G.

In: Annals of internal medicine, Vol. 104, No. 2, 01.01.1986, p. 163-168.

Research output: Contribution to journalArticle

Jagannath, S. ; Dicke, K. A. ; Armitage, J. O. ; Cabanillas, F. F. ; Horwitz, L. J. ; Vellekoop, L. ; Zander, A. R. ; Spitzer, G. / High-dose cyclophosphamide, carmustine, and etoposide and autologous bone marrow transplantation for relapsed Hodgkin's disease. In: Annals of internal medicine. 1986 ; Vol. 104, No. 2. pp. 163-168.
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