Hiding in plain sight

Interplay between staphylococcal biofilms and host immunity

Tyler D. Scherr, Cortney E. Heim, John M. Morrison, Tammy L Kielian

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Staphylococcus aureus and Staphylococcus epidermidis are notable for their propensity to form biofilms on implanted medical devices. Staphylococcal biofilm infections are typified by their recalcitrance to antibiotics and ability to circumvent host immune-mediated clearance, resulting in the establishment of chronic infections that are often recurrent in nature. Indeed, the immunomodulatory lifestyle of biofilms seemingly shapes the host immune response to ensure biofilm engraftment and persistence in an immune competent host. Here, we provide a brief review of the mechanisms whereby S. aureus and S. epidermidis biofilms manipulate host-pathogen interactions and discuss the concept of microenvironment maintenance in infectious outcomes, as well as speculate how these findings pertain to the challenges of staphylococcal vaccine development.

Original languageEnglish (US)
Article numberArticle 37
JournalFrontiers in immunology
Volume5
Issue numberFEB
DOIs
StatePublished - Jan 1 2014

Fingerprint

Biofilms
Immunity
Staphylococcus epidermidis
Staphylococcal Vaccines
Staphylococcus aureus
Host-Pathogen Interactions
Staphylococcal Infections
Aptitude
Life Style
Maintenance
Anti-Bacterial Agents
Equipment and Supplies
Infection

Keywords

  • Biofilm
  • Macrophage
  • Neutrophil
  • Staphylococcus aureus
  • Staphylococcus epidermidis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Hiding in plain sight : Interplay between staphylococcal biofilms and host immunity. / Scherr, Tyler D.; Heim, Cortney E.; Morrison, John M.; Kielian, Tammy L.

In: Frontiers in immunology, Vol. 5, No. FEB, Article 37, 01.01.2014.

Research output: Contribution to journalArticle

Scherr, Tyler D. ; Heim, Cortney E. ; Morrison, John M. ; Kielian, Tammy L. / Hiding in plain sight : Interplay between staphylococcal biofilms and host immunity. In: Frontiers in immunology. 2014 ; Vol. 5, No. FEB.
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