Heterozygous α1-antitrypsin phenotypes in patients with end stage liver disease

Marsha L. Eigenbrodt, Timothy M McCashland, Robert M. Dy, James Clark, Joseph Galati

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objective: The objective of the study was to determine the prevalence and associations of abnormal α1-antitrypsin phenotypes in Caucasian adults with end stage liver disease with particular emphasis on heterozygous phenotypes and disease from hepatitis C virus. Methods: All patients (788) with end stage liver disease considered for liver transplantation from July 1990 to June 1996 in a referral-based university hospital transplant center (University of Nebraska Medical Center, Omaha, NE) comprised the study population. Data for the study population was determined by retrospective review of the transplantation database at the transplant center. Hepatitis C virus infection was determined by a second generation ELISA method, and α1- antitrypsin phenotyping was performed on agarose gel with serum quantitation using a Behring Nephelometer. Results: Among 683 Caucasian patients with severe liver disease, the prevalences of Pi ZZ, Pi MZ, and Pi MS were 0.4, 7.3, and 8.2%, respectively, compared with 0, 2.8, and 4.2% in the control population. The odds of having a heterozygous Z phenotype were significantly increased in Caucasian patients with hepatitis C virus (odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.1-9.0), alcoholic liver disease (OR = 5.0, 95% CI = 2.6-9.6), primary hepatic malignancy (OR = 7.4, 95% CI = 2.9- 19.0), and cryptogenic cirrhosis (OR = 2.6, 95% CI = 1.1-6.3) compared with the control population. Caucasian patients with hepatitis C or B virus were 3.6 times more likely to have a heterozygous Z phenotype than a normal phenotype compared with patients with diseases of autoimmune etiology. Conclusion: This study provides evidence of an association of heterozygous Z α1-antitrypsin phenotype with end stage liver disease of several etiologies, not hepatitis C virus alone.

Original languageEnglish (US)
Pages (from-to)602-607
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume92
Issue number4
StatePublished - Apr 1 1997

Fingerprint

End Stage Liver Disease
Hepacivirus
Phenotype
Odds Ratio
Confidence Intervals
Population
Transplants
Alcoholic Liver Diseases
Virus Diseases
Hepatitis B virus
Liver Transplantation
Sepharose
Autoimmune Diseases
Liver Diseases
Referral and Consultation
Transplantation
Gels
Enzyme-Linked Immunosorbent Assay
Databases
Liver

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Heterozygous α1-antitrypsin phenotypes in patients with end stage liver disease. / Eigenbrodt, Marsha L.; McCashland, Timothy M; Dy, Robert M.; Clark, James; Galati, Joseph.

In: American Journal of Gastroenterology, Vol. 92, No. 4, 01.04.1997, p. 602-607.

Research output: Contribution to journalArticle

Eigenbrodt, Marsha L. ; McCashland, Timothy M ; Dy, Robert M. ; Clark, James ; Galati, Joseph. / Heterozygous α1-antitrypsin phenotypes in patients with end stage liver disease. In: American Journal of Gastroenterology. 1997 ; Vol. 92, No. 4. pp. 602-607.
@article{d0cdc56521274d9eac127ac408e490f1,
title = "Heterozygous α1-antitrypsin phenotypes in patients with end stage liver disease",
abstract = "Objective: The objective of the study was to determine the prevalence and associations of abnormal α1-antitrypsin phenotypes in Caucasian adults with end stage liver disease with particular emphasis on heterozygous phenotypes and disease from hepatitis C virus. Methods: All patients (788) with end stage liver disease considered for liver transplantation from July 1990 to June 1996 in a referral-based university hospital transplant center (University of Nebraska Medical Center, Omaha, NE) comprised the study population. Data for the study population was determined by retrospective review of the transplantation database at the transplant center. Hepatitis C virus infection was determined by a second generation ELISA method, and α1- antitrypsin phenotyping was performed on agarose gel with serum quantitation using a Behring Nephelometer. Results: Among 683 Caucasian patients with severe liver disease, the prevalences of Pi ZZ, Pi MZ, and Pi MS were 0.4, 7.3, and 8.2{\%}, respectively, compared with 0, 2.8, and 4.2{\%} in the control population. The odds of having a heterozygous Z phenotype were significantly increased in Caucasian patients with hepatitis C virus (odds ratio (OR) = 4.3, 95{\%} confidence interval (CI) = 2.1-9.0), alcoholic liver disease (OR = 5.0, 95{\%} CI = 2.6-9.6), primary hepatic malignancy (OR = 7.4, 95{\%} CI = 2.9- 19.0), and cryptogenic cirrhosis (OR = 2.6, 95{\%} CI = 1.1-6.3) compared with the control population. Caucasian patients with hepatitis C or B virus were 3.6 times more likely to have a heterozygous Z phenotype than a normal phenotype compared with patients with diseases of autoimmune etiology. Conclusion: This study provides evidence of an association of heterozygous Z α1-antitrypsin phenotype with end stage liver disease of several etiologies, not hepatitis C virus alone.",
author = "Eigenbrodt, {Marsha L.} and McCashland, {Timothy M} and Dy, {Robert M.} and James Clark and Joseph Galati",
year = "1997",
month = "4",
day = "1",
language = "English (US)",
volume = "92",
pages = "602--607",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Heterozygous α1-antitrypsin phenotypes in patients with end stage liver disease

AU - Eigenbrodt, Marsha L.

AU - McCashland, Timothy M

AU - Dy, Robert M.

AU - Clark, James

AU - Galati, Joseph

PY - 1997/4/1

Y1 - 1997/4/1

N2 - Objective: The objective of the study was to determine the prevalence and associations of abnormal α1-antitrypsin phenotypes in Caucasian adults with end stage liver disease with particular emphasis on heterozygous phenotypes and disease from hepatitis C virus. Methods: All patients (788) with end stage liver disease considered for liver transplantation from July 1990 to June 1996 in a referral-based university hospital transplant center (University of Nebraska Medical Center, Omaha, NE) comprised the study population. Data for the study population was determined by retrospective review of the transplantation database at the transplant center. Hepatitis C virus infection was determined by a second generation ELISA method, and α1- antitrypsin phenotyping was performed on agarose gel with serum quantitation using a Behring Nephelometer. Results: Among 683 Caucasian patients with severe liver disease, the prevalences of Pi ZZ, Pi MZ, and Pi MS were 0.4, 7.3, and 8.2%, respectively, compared with 0, 2.8, and 4.2% in the control population. The odds of having a heterozygous Z phenotype were significantly increased in Caucasian patients with hepatitis C virus (odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.1-9.0), alcoholic liver disease (OR = 5.0, 95% CI = 2.6-9.6), primary hepatic malignancy (OR = 7.4, 95% CI = 2.9- 19.0), and cryptogenic cirrhosis (OR = 2.6, 95% CI = 1.1-6.3) compared with the control population. Caucasian patients with hepatitis C or B virus were 3.6 times more likely to have a heterozygous Z phenotype than a normal phenotype compared with patients with diseases of autoimmune etiology. Conclusion: This study provides evidence of an association of heterozygous Z α1-antitrypsin phenotype with end stage liver disease of several etiologies, not hepatitis C virus alone.

AB - Objective: The objective of the study was to determine the prevalence and associations of abnormal α1-antitrypsin phenotypes in Caucasian adults with end stage liver disease with particular emphasis on heterozygous phenotypes and disease from hepatitis C virus. Methods: All patients (788) with end stage liver disease considered for liver transplantation from July 1990 to June 1996 in a referral-based university hospital transplant center (University of Nebraska Medical Center, Omaha, NE) comprised the study population. Data for the study population was determined by retrospective review of the transplantation database at the transplant center. Hepatitis C virus infection was determined by a second generation ELISA method, and α1- antitrypsin phenotyping was performed on agarose gel with serum quantitation using a Behring Nephelometer. Results: Among 683 Caucasian patients with severe liver disease, the prevalences of Pi ZZ, Pi MZ, and Pi MS were 0.4, 7.3, and 8.2%, respectively, compared with 0, 2.8, and 4.2% in the control population. The odds of having a heterozygous Z phenotype were significantly increased in Caucasian patients with hepatitis C virus (odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.1-9.0), alcoholic liver disease (OR = 5.0, 95% CI = 2.6-9.6), primary hepatic malignancy (OR = 7.4, 95% CI = 2.9- 19.0), and cryptogenic cirrhosis (OR = 2.6, 95% CI = 1.1-6.3) compared with the control population. Caucasian patients with hepatitis C or B virus were 3.6 times more likely to have a heterozygous Z phenotype than a normal phenotype compared with patients with diseases of autoimmune etiology. Conclusion: This study provides evidence of an association of heterozygous Z α1-antitrypsin phenotype with end stage liver disease of several etiologies, not hepatitis C virus alone.

UR - http://www.scopus.com/inward/record.url?scp=0030999090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030999090&partnerID=8YFLogxK

M3 - Article

C2 - 9128307

AN - SCOPUS:0030999090

VL - 92

SP - 602

EP - 607

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 4

ER -