Heteromorphism of C-band positive chromosomal regions in CML patients

Siddharth G. Adhvaryu, Bhavana J. Dave, Amit H. Trivedi, Kalyani H. Jani, Rohini C. Vyas

Research output: Contribution to journalArticle

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Abstract

The heteromorphism of constitutive heterochromatin in chromosomes #1, #9, and #16 was investigated in 44 chronic myelocytic leukemia patients and 44 controls using bone marrow and peripheral blood lymphocyte cultures. A significant increase in the length of C-band region in all the three chromosome pairs as well as a statistically significant difference in the homologs of chromosome #1 was observed in chronic myelocytic leukemia patients when compared with the controls. The frequency of inversions was also greater in the patients than in the controls. A random translocation of 22q was found on either homolog of chromosome #9.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalCancer genetics and cytogenetics
Volume27
Issue number1
DOIs
StatePublished - Jul 1987

Fingerprint

Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 1
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Heterochromatin
Chromosomes
Bone Marrow
Lymphocytes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Heteromorphism of C-band positive chromosomal regions in CML patients. / Adhvaryu, Siddharth G.; Dave, Bhavana J.; Trivedi, Amit H.; Jani, Kalyani H.; Vyas, Rohini C.

In: Cancer genetics and cytogenetics, Vol. 27, No. 1, 07.1987, p. 33-38.

Research output: Contribution to journalArticle

Adhvaryu, Siddharth G. ; Dave, Bhavana J. ; Trivedi, Amit H. ; Jani, Kalyani H. ; Vyas, Rohini C. / Heteromorphism of C-band positive chromosomal regions in CML patients. In: Cancer genetics and cytogenetics. 1987 ; Vol. 27, No. 1. pp. 33-38.
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