Heterogeneity in behavioral treatment response in severe mental illness

Jason Peer, Eric Strachan, William D Spaulding

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An exploratory investigation of behavioral treatment response during inpatient rehabilitation for severe mental illness is presented. Archival data from 26 weeks of behavioral contingency management (CM) programs targeting treatment nonadherence for 2 cohorts of participants were analyzed. For cohort 1 (N = 39), a multivariate analysis of longitudinal behavioral data identified 4 qualitatively and quantitatively distinct patterns of CM response and these groups differed in verbal memory ability. Analysis of cohort 2 (N = 45) replicated the finding of 4 patterns of CM response. We further clarified behavioral heterogeneity in cohort 2 by using hierarchical linear modeling with neurocognitive and social cognitive covariates. Results indicated that memory, attention, and a high external locus of control (LOC) were associated with level of nonadherence at baseline. Reductions in external locus of control were associated with greater CM response during the course of rehabilitation. Implications for understanding individual responses to the rehabilitation process are discussed.

Original languageEnglish (US)
Pages (from-to)198-206
Number of pages9
JournalJournal of Nervous and Mental Disease
Volume196
Issue number3
DOIs
StatePublished - Mar 1 2008

Fingerprint

Internal-External Control
Rehabilitation
Aptitude
Inpatients
Cohort Studies
Therapeutics
Multivariate Analysis

Keywords

  • Contingency management
  • Heterogeneity
  • Inpatient psychiatric rehabilitation
  • Severe mental illness

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Heterogeneity in behavioral treatment response in severe mental illness. / Peer, Jason; Strachan, Eric; Spaulding, William D.

In: Journal of Nervous and Mental Disease, Vol. 196, No. 3, 01.03.2008, p. 198-206.

Research output: Contribution to journalArticle

@article{ff74aeafcc8443c78a858ec2fb31b9f0,
title = "Heterogeneity in behavioral treatment response in severe mental illness",
abstract = "An exploratory investigation of behavioral treatment response during inpatient rehabilitation for severe mental illness is presented. Archival data from 26 weeks of behavioral contingency management (CM) programs targeting treatment nonadherence for 2 cohorts of participants were analyzed. For cohort 1 (N = 39), a multivariate analysis of longitudinal behavioral data identified 4 qualitatively and quantitatively distinct patterns of CM response and these groups differed in verbal memory ability. Analysis of cohort 2 (N = 45) replicated the finding of 4 patterns of CM response. We further clarified behavioral heterogeneity in cohort 2 by using hierarchical linear modeling with neurocognitive and social cognitive covariates. Results indicated that memory, attention, and a high external locus of control (LOC) were associated with level of nonadherence at baseline. Reductions in external locus of control were associated with greater CM response during the course of rehabilitation. Implications for understanding individual responses to the rehabilitation process are discussed.",
keywords = "Contingency management, Heterogeneity, Inpatient psychiatric rehabilitation, Severe mental illness",
author = "Jason Peer and Eric Strachan and Spaulding, {William D}",
year = "2008",
month = "3",
day = "1",
doi = "10.1097/NMD.0b013e318165c7d2",
language = "English (US)",
volume = "196",
pages = "198--206",
journal = "Journal of Nervous and Mental Disease",
issn = "0022-3018",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Heterogeneity in behavioral treatment response in severe mental illness

AU - Peer, Jason

AU - Strachan, Eric

AU - Spaulding, William D

PY - 2008/3/1

Y1 - 2008/3/1

N2 - An exploratory investigation of behavioral treatment response during inpatient rehabilitation for severe mental illness is presented. Archival data from 26 weeks of behavioral contingency management (CM) programs targeting treatment nonadherence for 2 cohorts of participants were analyzed. For cohort 1 (N = 39), a multivariate analysis of longitudinal behavioral data identified 4 qualitatively and quantitatively distinct patterns of CM response and these groups differed in verbal memory ability. Analysis of cohort 2 (N = 45) replicated the finding of 4 patterns of CM response. We further clarified behavioral heterogeneity in cohort 2 by using hierarchical linear modeling with neurocognitive and social cognitive covariates. Results indicated that memory, attention, and a high external locus of control (LOC) were associated with level of nonadherence at baseline. Reductions in external locus of control were associated with greater CM response during the course of rehabilitation. Implications for understanding individual responses to the rehabilitation process are discussed.

AB - An exploratory investigation of behavioral treatment response during inpatient rehabilitation for severe mental illness is presented. Archival data from 26 weeks of behavioral contingency management (CM) programs targeting treatment nonadherence for 2 cohorts of participants were analyzed. For cohort 1 (N = 39), a multivariate analysis of longitudinal behavioral data identified 4 qualitatively and quantitatively distinct patterns of CM response and these groups differed in verbal memory ability. Analysis of cohort 2 (N = 45) replicated the finding of 4 patterns of CM response. We further clarified behavioral heterogeneity in cohort 2 by using hierarchical linear modeling with neurocognitive and social cognitive covariates. Results indicated that memory, attention, and a high external locus of control (LOC) were associated with level of nonadherence at baseline. Reductions in external locus of control were associated with greater CM response during the course of rehabilitation. Implications for understanding individual responses to the rehabilitation process are discussed.

KW - Contingency management

KW - Heterogeneity

KW - Inpatient psychiatric rehabilitation

KW - Severe mental illness

UR - http://www.scopus.com/inward/record.url?scp=40949161512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40949161512&partnerID=8YFLogxK

U2 - 10.1097/NMD.0b013e318165c7d2

DO - 10.1097/NMD.0b013e318165c7d2

M3 - Article

VL - 196

SP - 198

EP - 206

JO - Journal of Nervous and Mental Disease

JF - Journal of Nervous and Mental Disease

SN - 0022-3018

IS - 3

ER -