Herpesvirus ateles and herpesvirus saimiri transform marmoset T cells into continuously proliferating cell lines that can mediate natural killer cell-like cytotoxicity

Donald R Johnson, M. Jondal

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Herpesvirus ateles (HVA) and herpesvirus saimiri (HVS) have the capacity to transform cotton-topped marmoset T lymphocytes into continuously proliferating cell lines that retain some functions associated with cell-mediated immunity. In the present paper, we demonstrate that HVA/HVS-transformed T cell lines are cytotoxic in a short-term 51Cr release assay and that this killing resembles killing by marmoset natural killer (NK) cells. The relationship between NK cells and HVA/HVS-transformed killer cell lines is discussed in view of present knowledge of the origin and function of the NK system. It is suggested that the described cytotoxic cell lines may be useful for further defining cellular cytotoxicity with regard to cell surface recognition, regulatory events, and lytic mechanisms.

Original languageEnglish (US)
Pages (from-to)6391-6395
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume78
Issue number10 I
DOIs
StatePublished - Jan 1 1981

Fingerprint

Rhadinovirus
Saimiriine Herpesvirus 2
Callithrix
Natural Killer Cells
Transformed Cell Line
T-Lymphocytes
Cell Line
Cellular Immunity

ASJC Scopus subject areas

  • General

Cite this

@article{8f67a6437f0a4c65adf93b422505b34e,
title = "Herpesvirus ateles and herpesvirus saimiri transform marmoset T cells into continuously proliferating cell lines that can mediate natural killer cell-like cytotoxicity",
abstract = "Herpesvirus ateles (HVA) and herpesvirus saimiri (HVS) have the capacity to transform cotton-topped marmoset T lymphocytes into continuously proliferating cell lines that retain some functions associated with cell-mediated immunity. In the present paper, we demonstrate that HVA/HVS-transformed T cell lines are cytotoxic in a short-term 51Cr release assay and that this killing resembles killing by marmoset natural killer (NK) cells. The relationship between NK cells and HVA/HVS-transformed killer cell lines is discussed in view of present knowledge of the origin and function of the NK system. It is suggested that the described cytotoxic cell lines may be useful for further defining cellular cytotoxicity with regard to cell surface recognition, regulatory events, and lytic mechanisms.",
author = "Johnson, {Donald R} and M. Jondal",
year = "1981",
month = "1",
day = "1",
doi = "10.1073/pnas.78.10.6391",
language = "English (US)",
volume = "78",
pages = "6391--6395",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "10 I",

}

TY - JOUR

T1 - Herpesvirus ateles and herpesvirus saimiri transform marmoset T cells into continuously proliferating cell lines that can mediate natural killer cell-like cytotoxicity

AU - Johnson, Donald R

AU - Jondal, M.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Herpesvirus ateles (HVA) and herpesvirus saimiri (HVS) have the capacity to transform cotton-topped marmoset T lymphocytes into continuously proliferating cell lines that retain some functions associated with cell-mediated immunity. In the present paper, we demonstrate that HVA/HVS-transformed T cell lines are cytotoxic in a short-term 51Cr release assay and that this killing resembles killing by marmoset natural killer (NK) cells. The relationship between NK cells and HVA/HVS-transformed killer cell lines is discussed in view of present knowledge of the origin and function of the NK system. It is suggested that the described cytotoxic cell lines may be useful for further defining cellular cytotoxicity with regard to cell surface recognition, regulatory events, and lytic mechanisms.

AB - Herpesvirus ateles (HVA) and herpesvirus saimiri (HVS) have the capacity to transform cotton-topped marmoset T lymphocytes into continuously proliferating cell lines that retain some functions associated with cell-mediated immunity. In the present paper, we demonstrate that HVA/HVS-transformed T cell lines are cytotoxic in a short-term 51Cr release assay and that this killing resembles killing by marmoset natural killer (NK) cells. The relationship between NK cells and HVA/HVS-transformed killer cell lines is discussed in view of present knowledge of the origin and function of the NK system. It is suggested that the described cytotoxic cell lines may be useful for further defining cellular cytotoxicity with regard to cell surface recognition, regulatory events, and lytic mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=0019785172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019785172&partnerID=8YFLogxK

U2 - 10.1073/pnas.78.10.6391

DO - 10.1073/pnas.78.10.6391

M3 - Article

VL - 78

SP - 6391

EP - 6395

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 10 I

ER -