Heritability of lung function in severe alpha-1 antitrypsin deficiency

D. L. DeMeo, E. J. Campbell, M. L. Brantly, A. F. Barker, E. Eden, N. G. McElvaney, S. I. Rennard, J. M. Stocks, J. K. Stoller, C. Strange, G. Turino, R. A. Sandhaus, E. K. Silverman

Research output: Contribution to journalArticle

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Abstract

Severe alpha-1 antitrypsin (AAT) deficiency is a proven genetic risk factor for COPD, but there is marked variation in the development of COPD among AAT deficient subjects. To investigate familial aggregation of lung function in subjects with AAT deficiency, we estimated heritability for forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) in 378 AAT deficient subjects from 167 families in the AAT Genetic Modifiers Study; all subjects were verified homozygous for the Z AAT deficiency allele. Heritability was evaluated for models that included and excluded an ascertainment correction, as well as for models that excluded, included and were stratified by a cigarette smoking covariate. In models without an ascertainment correction, and in all models without a covariate for smoking, no evidence for familial aggregation of lung function was observed. In models conditioned on the index proband with covariates for smoking, post-bronchodilator FEV 1/FVC demonstrated significant heritability (0.26 ± 0.14, p = 0.03). When we limited the analysis to subjects with a smoking history, post-bronchodilator FEV1demonstrated significant heritability (0.47 ± 0.21, p = 0.02). Severity rate phenotypes were also assessed as potential phenotypes for genetic modifier studies. Significant heritability was found with all age-of-onset threshold models that included smoking and ascertainment adjustments. Using the t-distribution, the heritability estimates ranged from 0.43 to 0.64, depending on the age-of-onset of FEV1 decline used for the severity rate calculation. Correction for ascertainment and consideration of gene-by-smoking interactions will be crucial for the identification of genes that may modify susceptibility for COPD in families with AAT deficiency.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalHuman Heredity
Volume67
Issue number1
DOIs
StatePublished - Nov 1 2008

Fingerprint

alpha 1-Antitrypsin Deficiency
Smoking
Lung
alpha 1-Antitrypsin
Forced Expiratory Volume
Chronic Obstructive Pulmonary Disease
Bronchodilator Agents
Vital Capacity
Age of Onset
Phenotype
Social Adjustment
Genes
Autosomal Recessive alpha-1-Antitrypsin Deficiency
History
Alleles

Keywords

  • Alpha-1 antitrypsin deficiency
  • Familial aggregation
  • Heritability
  • Modifier genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

DeMeo, D. L., Campbell, E. J., Brantly, M. L., Barker, A. F., Eden, E., McElvaney, N. G., ... Silverman, E. K. (2008). Heritability of lung function in severe alpha-1 antitrypsin deficiency. Human Heredity, 67(1), 38-45. https://doi.org/10.1159/000164397

Heritability of lung function in severe alpha-1 antitrypsin deficiency. / DeMeo, D. L.; Campbell, E. J.; Brantly, M. L.; Barker, A. F.; Eden, E.; McElvaney, N. G.; Rennard, S. I.; Stocks, J. M.; Stoller, J. K.; Strange, C.; Turino, G.; Sandhaus, R. A.; Silverman, E. K.

In: Human Heredity, Vol. 67, No. 1, 01.11.2008, p. 38-45.

Research output: Contribution to journalArticle

DeMeo, DL, Campbell, EJ, Brantly, ML, Barker, AF, Eden, E, McElvaney, NG, Rennard, SI, Stocks, JM, Stoller, JK, Strange, C, Turino, G, Sandhaus, RA & Silverman, EK 2008, 'Heritability of lung function in severe alpha-1 antitrypsin deficiency', Human Heredity, vol. 67, no. 1, pp. 38-45. https://doi.org/10.1159/000164397
DeMeo DL, Campbell EJ, Brantly ML, Barker AF, Eden E, McElvaney NG et al. Heritability of lung function in severe alpha-1 antitrypsin deficiency. Human Heredity. 2008 Nov 1;67(1):38-45. https://doi.org/10.1159/000164397
DeMeo, D. L. ; Campbell, E. J. ; Brantly, M. L. ; Barker, A. F. ; Eden, E. ; McElvaney, N. G. ; Rennard, S. I. ; Stocks, J. M. ; Stoller, J. K. ; Strange, C. ; Turino, G. ; Sandhaus, R. A. ; Silverman, E. K. / Heritability of lung function in severe alpha-1 antitrypsin deficiency. In: Human Heredity. 2008 ; Vol. 67, No. 1. pp. 38-45.
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