Hereditary ovarian carcinoma. Biomarker studies

Henry T. Lynch, Guy S. Schuelke, Ibert C. Wells, Shih‐Chuan ‐C Cheng, William J Kimberling, Karen A. Biscone, Jane F. Lynch, B. Shannon Danes

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Three ovarian‐cancer‐prone kindreds were studied, two of which contained identical twin sisters concordant for ovarian carcinoma. In one kindred, both identical twin sisters had daughters with ovarian carcinoma. In another kindred, one of the identical twin sisters had an ovarian‐cancer‐affected daughter. Ovarian carcinoma showed vertical transmission in all three families in a pattern consonant with an autosomal dominant mode of inheritance. Medical‐genetic survey of each family included detailed questionnaires with retrieval of primary medical and pathology documents on cancer of all anatomic sites. Putative biomarker determinations included: (1) in vitro hyperdiploidy in dermal monolayer cultures; and (2) lower serum levels of alpha‐L‐fucosidase (≤ 275 IU/ml) in all cancer‐affected patients and statistically significant lower levels in 50% risk individuals when compared to spouse and published controls (P = 0.04 and P = 0.0002, respectively). These findings are discussed in context with the eventual development of a risk factor profile which, given acceptable sensitivity and specificity, would enable identification of individuals who would be prime candidates for intensive surveillance/management programs.

Original languageEnglish (US)
Pages (from-to)410-415
Number of pages6
JournalCancer
Volume55
Issue number2
DOIs
StatePublished - Jan 1 1985

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Monozygotic Twins
Siblings
Biomarkers
Carcinoma
Nuclear Family
Polyploidy
Spouses
Pathology
Sensitivity and Specificity
Skin
Serum
Neoplasms
Surveys and Questionnaires

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Lynch, H. T., Schuelke, G. S., Wells, I. C., Cheng, SC. C., Kimberling, W. J., Biscone, K. A., ... Danes, B. S. (1985). Hereditary ovarian carcinoma. Biomarker studies. Cancer, 55(2), 410-415. https://doi.org/10.1002/1097-0142(19850115)55:2<410::AID-CNCR2820550220>3.0.CO;2-Q

Hereditary ovarian carcinoma. Biomarker studies. / Lynch, Henry T.; Schuelke, Guy S.; Wells, Ibert C.; Cheng, Shih‐Chuan ‐C; Kimberling, William J; Biscone, Karen A.; Lynch, Jane F.; Danes, B. Shannon.

In: Cancer, Vol. 55, No. 2, 01.01.1985, p. 410-415.

Research output: Contribution to journalArticle

Lynch, HT, Schuelke, GS, Wells, IC, Cheng, SCC, Kimberling, WJ, Biscone, KA, Lynch, JF & Danes, BS 1985, 'Hereditary ovarian carcinoma. Biomarker studies', Cancer, vol. 55, no. 2, pp. 410-415. https://doi.org/10.1002/1097-0142(19850115)55:2<410::AID-CNCR2820550220>3.0.CO;2-Q
Lynch HT, Schuelke GS, Wells IC, Cheng SCC, Kimberling WJ, Biscone KA et al. Hereditary ovarian carcinoma. Biomarker studies. Cancer. 1985 Jan 1;55(2):410-415. https://doi.org/10.1002/1097-0142(19850115)55:2<410::AID-CNCR2820550220>3.0.CO;2-Q
Lynch, Henry T. ; Schuelke, Guy S. ; Wells, Ibert C. ; Cheng, Shih‐Chuan ‐C ; Kimberling, William J ; Biscone, Karen A. ; Lynch, Jane F. ; Danes, B. Shannon. / Hereditary ovarian carcinoma. Biomarker studies. In: Cancer. 1985 ; Vol. 55, No. 2. pp. 410-415.
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