Hepatitis G virus infection before and after liver transplantation

J. H. Hoofnagle, M. Lombardero, Y. Wei, J. Everhart, R. Wiesner, Rowen K Zetterman, A. J. Yun, L. Yang, J. P. Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The hepatitis G virus is a newly discovered flavivirus that has been linked to acute and chronic hepatitis of unknown cause. We determined the prevalence of hepatitis G virus infection in 179 selected patients undergoing liver transplantation at three centers participating in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Liver Transplantation Database. Pretransplantation and posttransplantation specimens were tested for hepatitis G virus RNA by polymerase chain reaction. Before transplantation, 9 of 38 (24%) patients with fulminant hepatic failure, 9 of 62 (15%) with cryptogenic cirrhosis, 3 of 35 (9%) with cholestatic liver disease, and 5 of 44 (11%) with chronic hepatitis C were positive for hepatitis G virus RNA (P = .27). Patients with and without viral RNA were similar in clinical features, liver test abnormalities, and survival after transplantation posttransplantation serum specimens were tested from 73 patients; 9 of 11 (82%) who were positive for viral RNA before transplantation remained positive, but 35 of 62 (56%) patients who were initially negative became positive after transplantation, a rate consistent with that predicted from the number of blood products administered. Only 5% of de hove HGV infections could be attributed to preexisting hepatitis G virus RNA in the donor. Comparison of patients with and without hepatitis G virus infection showed no difference in incidence of hepatitis after transplantation. Thus, hepatitis G virus infection was present in 15% of patients before and appeared de novo in half of patients after liver transplantation. Although hepatitis G virus infection was not associated with poor outcome, the frequency of this infection after transplantation calls for further long-term evaluation.

Original languageEnglish (US)
Pages (from-to)578-585
Number of pages8
JournalLiver Transplantation and Surgery
Volume3
Issue number6
DOIs
StatePublished - Jan 1 1997

Fingerprint

GB virus C
Virus Diseases
Liver Transplantation
Transplantation
Viral RNA
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
RNA
Flavivirus
Acute Liver Failure
Chronic Hepatitis C
DNA-Directed RNA Polymerases
Chronic Hepatitis
Infection
Hepatitis
Liver Diseases
Tissue Donors
Databases
Polymerase Chain Reaction
Survival

ASJC Scopus subject areas

  • Surgery
  • Hepatology

Cite this

Hoofnagle, J. H., Lombardero, M., Wei, Y., Everhart, J., Wiesner, R., Zetterman, R. K., ... Kim, J. P. (1997). Hepatitis G virus infection before and after liver transplantation. Liver Transplantation and Surgery, 3(6), 578-585. https://doi.org/10.1002/lt.500030604

Hepatitis G virus infection before and after liver transplantation. / Hoofnagle, J. H.; Lombardero, M.; Wei, Y.; Everhart, J.; Wiesner, R.; Zetterman, Rowen K; Yun, A. J.; Yang, L.; Kim, J. P.

In: Liver Transplantation and Surgery, Vol. 3, No. 6, 01.01.1997, p. 578-585.

Research output: Contribution to journalArticle

Hoofnagle, JH, Lombardero, M, Wei, Y, Everhart, J, Wiesner, R, Zetterman, RK, Yun, AJ, Yang, L & Kim, JP 1997, 'Hepatitis G virus infection before and after liver transplantation', Liver Transplantation and Surgery, vol. 3, no. 6, pp. 578-585. https://doi.org/10.1002/lt.500030604
Hoofnagle, J. H. ; Lombardero, M. ; Wei, Y. ; Everhart, J. ; Wiesner, R. ; Zetterman, Rowen K ; Yun, A. J. ; Yang, L. ; Kim, J. P. / Hepatitis G virus infection before and after liver transplantation. In: Liver Transplantation and Surgery. 1997 ; Vol. 3, No. 6. pp. 578-585.
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