Hepatitis C virus and other risk factors in hepatocellular carcinoma

E. Schiefelbein, A. R. Zekri, D. W. Newton, G. A. Soliman, M. Banerjee, C. H.W. Hung, I. A. Seifeldin, A. C.H. Lo, A. S. Soliman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) increased in Egypt in the past years, becoming the most common cancer among men. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the known primary risk factors for HCC. This study describes the viral profile of HCC in a predominantly rural area in Egypt. We included 148 HCC cases and 148 controls from the Tanta Cancer Center and the Gharbiah Cancer Society in the Nile delta region. Serological (ELISA) and molecular (PCR) analysis for HBV and HCV infection were performed on plasma samples from each subject. Epidemiologic, environmental, and medical histories were collected by interviewing of subjects. Around 90.5% of cases and controls were from rural areas. HCV infection was high in both cases and controls (89.2% and 49.3%, for cases and controls respectively by serology). HCV was the most important HCC risk factor [OR 9.7 (95% CI: 3.3-28.0, P <0.01)], and HBV infection showed marginal tendency of increased risk [OR 5.4 (95% CI: 0.9-31.8, P <0.06)]. Ever worked in farming [OR 2.8 (95% CI: 1.1-7.2, P <0.03)] and history of cirrhosis [OR 3.6 (95% CI: 1.6-8.1, P <0.01)] or blood transfusion [OR 4.2 (95% CI: 0.99-17.8, P <0.05)] were also associated with increased HCC risk. This study in a predominantly rural area in Egypt supports previous reports from other parts of Egypt that HCV infection is the primary HCC risk factor in Egypt. Further understanding of the relationship between infection and other risk factors in the development of HCC could lead to targeted interventions for at-risk individuals.

Original languageEnglish (US)
Pages (from-to)235-240
Number of pages6
JournalActa Virologica
Volume56
Issue number3
DOIs
StatePublished - Dec 1 2012

Fingerprint

Hepacivirus
Hepatocellular Carcinoma
Egypt
Virus Diseases
Hepatitis B virus
Benzydamine
Neoplasms
Serology
Agriculture
Blood Transfusion
Fibrosis
Enzyme-Linked Immunosorbent Assay
Polymerase Chain Reaction
Infection

Keywords

  • Egypt
  • Hepatitis
  • Hepatocellular carcinoma
  • Risk factors
  • Rural

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Schiefelbein, E., Zekri, A. R., Newton, D. W., Soliman, G. A., Banerjee, M., Hung, C. H. W., ... Soliman, A. S. (2012). Hepatitis C virus and other risk factors in hepatocellular carcinoma. Acta Virologica, 56(3), 235-240. https://doi.org/10.4149/av_2012_03_235

Hepatitis C virus and other risk factors in hepatocellular carcinoma. / Schiefelbein, E.; Zekri, A. R.; Newton, D. W.; Soliman, G. A.; Banerjee, M.; Hung, C. H.W.; Seifeldin, I. A.; Lo, A. C.H.; Soliman, A. S.

In: Acta Virologica, Vol. 56, No. 3, 01.12.2012, p. 235-240.

Research output: Contribution to journalArticle

Schiefelbein, E, Zekri, AR, Newton, DW, Soliman, GA, Banerjee, M, Hung, CHW, Seifeldin, IA, Lo, ACH & Soliman, AS 2012, 'Hepatitis C virus and other risk factors in hepatocellular carcinoma', Acta Virologica, vol. 56, no. 3, pp. 235-240. https://doi.org/10.4149/av_2012_03_235
Schiefelbein E, Zekri AR, Newton DW, Soliman GA, Banerjee M, Hung CHW et al. Hepatitis C virus and other risk factors in hepatocellular carcinoma. Acta Virologica. 2012 Dec 1;56(3):235-240. https://doi.org/10.4149/av_2012_03_235
Schiefelbein, E. ; Zekri, A. R. ; Newton, D. W. ; Soliman, G. A. ; Banerjee, M. ; Hung, C. H.W. ; Seifeldin, I. A. ; Lo, A. C.H. ; Soliman, A. S. / Hepatitis C virus and other risk factors in hepatocellular carcinoma. In: Acta Virologica. 2012 ; Vol. 56, No. 3. pp. 235-240.
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abstract = "Hepatocellular carcinoma (HCC) increased in Egypt in the past years, becoming the most common cancer among men. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the known primary risk factors for HCC. This study describes the viral profile of HCC in a predominantly rural area in Egypt. We included 148 HCC cases and 148 controls from the Tanta Cancer Center and the Gharbiah Cancer Society in the Nile delta region. Serological (ELISA) and molecular (PCR) analysis for HBV and HCV infection were performed on plasma samples from each subject. Epidemiologic, environmental, and medical histories were collected by interviewing of subjects. Around 90.5{\%} of cases and controls were from rural areas. HCV infection was high in both cases and controls (89.2{\%} and 49.3{\%}, for cases and controls respectively by serology). HCV was the most important HCC risk factor [OR 9.7 (95{\%} CI: 3.3-28.0, P <0.01)], and HBV infection showed marginal tendency of increased risk [OR 5.4 (95{\%} CI: 0.9-31.8, P <0.06)]. Ever worked in farming [OR 2.8 (95{\%} CI: 1.1-7.2, P <0.03)] and history of cirrhosis [OR 3.6 (95{\%} CI: 1.6-8.1, P <0.01)] or blood transfusion [OR 4.2 (95{\%} CI: 0.99-17.8, P <0.05)] were also associated with increased HCC risk. This study in a predominantly rural area in Egypt supports previous reports from other parts of Egypt that HCV infection is the primary HCC risk factor in Egypt. Further understanding of the relationship between infection and other risk factors in the development of HCC could lead to targeted interventions for at-risk individuals.",
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