Hepatic metabolism of glucose, galactose, and lactate after milk feeding in newborn lambs

S. B. Spedale, F. C. Battaglia, J. W. Sparks

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The purpose of this study was to test the ability of the liver to efficiently clear substrates absorbed from the gastrointestinal tract after a feeding before entry into the systemic circulation. We placed a hepatic vein (HV) catheter in utero at 135-140 days gestation. The lamb was then allowed to deliver spontaneously, and additional catheters were placed in the portal vein (PV) and femoral artery (FA) at 1-3 days postnatal age. After at least 2 days recovery, lambs were fasted overnight at 4-10 days of age and then allowed to nurse ad libitum. There was significant hepatic glucose release during fasting and after 80 min postprandially. No net hepatic uptake of glucose was observed before or after feeding. PV galactose was significantly greater than FA and HV from 40 to 160 min after feeding (P < 0.005). Hepatic glucose extraction was negligible in the fasted state (1 ± 3%) and increased after feeding to 75 ± 2% when PV galactose was <1.0 mM. There was a significant hepatic arteriovenous concentration difference of lactate (0.23 ± 0.03 mM) and of oxygen (0.27 ± 0.01 mM), which did not change significantly after feeding. The metabolic quotient for galactose increased significantly after feeding, such that galactose was the largest carbon contributor for postprandial hepatic carbon secretion. After a milk feeding, the newborn liver efficiently extracts galactose, lactate, and oxygen, but not glucose.

Original languageEnglish (US)
Pages (from-to)E46-E51
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume262
Issue number1 25-1
StatePublished - Feb 27 1992

Fingerprint

Galactose
Metabolism
Lactic Acid
Milk
Newborn Infant
Glucose
Liver
Portal Vein
Hepatic Veins
Femoral Artery
Catheters
Carbon
Oxygen
Liver Extracts
Aptitude
Femoral Vein
Gastrointestinal Tract
Fasting
Nurses
Pregnancy

Keywords

  • First-pass clearance
  • Liver
  • Neonate
  • Nutrition

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

Cite this

Hepatic metabolism of glucose, galactose, and lactate after milk feeding in newborn lambs. / Spedale, S. B.; Battaglia, F. C.; Sparks, J. W.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 262, No. 1 25-1, 27.02.1992, p. E46-E51.

Research output: Contribution to journalArticle

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