Hepatic Failure Associated with Imipramine Therapy

M. S. Shaefer, A. L. Edmunds, Rodney Smith Markin, R. P. Wood, T. J. Pillen, B. W. Shaw

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Imipramine, a widely used antidepressant, has rarely been associated with hepatic abnormalities. In the majority of reported cases, hepatic effects have been transient and readily reversible on discontinuation of the drug. We cared for an 11‐year‐old boy with hepatic failure and massive cell necrosis which followed treatment with imipramine for enuresis. This therapy led to fulminant hepatic failure and subsequent liver transplantation. 1990 Pharmacotherapy Publications Inc.

Original languageEnglish (US)
Pages (from-to)66-69
Number of pages4
JournalPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1990

Fingerprint

Imipramine
Liver Failure
Enuresis
Acute Liver Failure
Liver
Liver Transplantation
Antidepressive Agents
Publications
Necrosis
Drug Therapy
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Hepatic Failure Associated with Imipramine Therapy. / Shaefer, M. S.; Edmunds, A. L.; Markin, Rodney Smith; Wood, R. P.; Pillen, T. J.; Shaw, B. W.

In: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Vol. 10, No. 1, 01.01.1990, p. 66-69.

Research output: Contribution to journalArticle

Shaefer, M. S. ; Edmunds, A. L. ; Markin, Rodney Smith ; Wood, R. P. ; Pillen, T. J. ; Shaw, B. W. / Hepatic Failure Associated with Imipramine Therapy. In: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 1990 ; Vol. 10, No. 1. pp. 66-69.
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