Hepatic and Serum Lipid Patterns During Development of Phenobarbital Induced Fatty Livers in Rats (38226)

D. J. Tuma, Michael Floyd Sorrell, A. J. Barak

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Lipids were measured in the livers and sera of rats that had received phenobarbital injections for 3 days and 5 days. The same lipid patterns including free cholesterol, cholesterol esters, phospholipids, triglyceride and fatty acids were determined in the livers and sera of rats 3 days and 5 days following withdrawal of the drug. Liver lipids increased with time while the rats were injected with phenobarbital and decreased toward normal levels once the drug was withdrawn. During phenobarbital administration as well as during withdrawal the serum lipid levels did not change. These results suggest that decreased lipid transport and enhanced lipid mobilization may not play major roles in the induction of the phenobarbital fatty liver.

Original languageEnglish (US)
Pages (from-to)953-956
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume146
Issue number4
DOIs
StatePublished - Sep 1974

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Fatty Liver
Phenobarbital
Liver
Rats
Lipids
Serum
Lipid Mobilization
Cholesterol Esters
Pharmaceutical Preparations
Phospholipids
Triglycerides
Fatty Acids
Cholesterol
Injections

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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abstract = "Lipids were measured in the livers and sera of rats that had received phenobarbital injections for 3 days and 5 days. The same lipid patterns including free cholesterol, cholesterol esters, phospholipids, triglyceride and fatty acids were determined in the livers and sera of rats 3 days and 5 days following withdrawal of the drug. Liver lipids increased with time while the rats were injected with phenobarbital and decreased toward normal levels once the drug was withdrawn. During phenobarbital administration as well as during withdrawal the serum lipid levels did not change. These results suggest that decreased lipid transport and enhanced lipid mobilization may not play major roles in the induction of the phenobarbital fatty liver.",
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