Hemodynamic interference of serial stenoses and its impact on FFR and iFR measurements

Siyeong Ju, Linxia Gu

Research output: Contribution to journalArticle

Abstract

The hemodynamic interference of serial stenoses poses challenges for identifying the functional severity using the fractional flow reserve (FFR) method. The instantaneous wave-free ratio (iFR), i.e., the distal-to-proximal pressure ratio at 75% of diastole, was recently proposed to overcome the disadvantages of the FFR. However, the underlying mechanism remained ambiguous due to the lack of quantitative definition of hemodynamic interference. The objective of this study is to quantitatively define the hemodynamic interference and then examine its role on the FFR and iFR measurements. Pressure distributions, velocity fields, and Q-criterion which identifies vortices, were obtained through the computational fluid dynamics (CFD) for five cases with spacing ratios at 1, 3, 5, 7, and 10. The hemodynamic interference was identified using vortex structures which were quantified by Q-criterion. Results have shown that a spacing ratio of 7 or larger was interference-free. Serial stenoses with a closer spacing ratio led to a larger hemodynamic interference, and thus, larger errors in the FFR measurements compared to the spacing ratio of 7. Moreover, the underestimation of the first stenosis lesion has been observed, even in interference-free cases due to the nature of hyperemia. However, the hemodynamic interference of the serial stenoses has a negligible impact on the iFR measurement, regardless of the spacing ratio. Our results demonstrated that the quantification of the hemodynamic interference in serial stenoses provided a better understanding of its role on the pressure measurements, which could be further exploited for the optimal treatment of serial stenoses.

Original languageEnglish (US)
Article number279
JournalApplied Sciences (Switzerland)
Volume9
Issue number2
DOIs
StatePublished - Jan 14 2019

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hemodynamics
Hemodynamics
interference
spacing
Vortex flow
diastole
vortices
Pressure measurement
Pressure distribution
pressure ratio
Computational fluid dynamics
pressure measurement
computational fluid dynamics
pressure distribution
lesions
velocity distribution

Keywords

  • Computational fluid dynamics (CFD)
  • Fractional flow reserve (FFR)
  • Hemodynamic interference
  • Instantaneous wave-free ratio (iFR)
  • Local pressure fluctuation
  • Pressure recovery
  • Serial stenoses
  • Vortex structures

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

Cite this

Hemodynamic interference of serial stenoses and its impact on FFR and iFR measurements. / Ju, Siyeong; Gu, Linxia.

In: Applied Sciences (Switzerland), Vol. 9, No. 2, 279, 14.01.2019.

Research output: Contribution to journalArticle

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