Hemodynamic and metabolic effects of venoarterial cardiopulmonary support in coronary artery disease

Robert K. Stack, Gregory Pavlides, Ronald Miller, Joseph Bassett, John Cieszkowski, Vellapallil Gangadharan, Mark Sakwa, Paul Clancy, William W. O'Neill

Research output: Contribution to journalArticle

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Abstract

Coronary angioplasty was performed on 14 high-risk patients supported with venoarterial partial cardiopulmonary bypass. Hemodynamic, metabolic and physiologic parameters were monitored to assess the effect of cardiopulmonary support in conscious patients. Cardiopulmonary support caused a decrease in systolic (45 ± 17 to 27 ± 14 mm Hg, p < 0.001), diastolic (23 ± 12 to 14 ± 8 mm Hg, p < 0.005) and mean (29.7 ± 13.2 to 18 ± 9 mm Hg, p < 0.001) pulmonary artery pressures. Aortic systolic (129 ± 18 to 106 ± 17 mm Hg, p < 0.001), mean (89 ± 19 to 84 ± 19 mm Hg, p < 0.05) and pulse (64 ± 17 to 37 ± 16 mm Hg, p < 0.00001) pressures also decreased. Heart rate and aortic diastolic pressures were unchanged. End-systolic wall stress (122 ± 48 × 103 to 96 ± 44 × 103 dynes/cm2, p < 0.001) and left ventricular end-diastolic diameter (5.7 ± 0.8 to 5.5 ± 0.9 cm, p < 0.05) were reduced during partial cardiopulmonary bypass. After initiation of cardiopulmonary support, normal lactate extraction across the coronary circulation was diminished or converted to lactate production (38 ± 23 to 2 ± 29%, p < 0.005). There was a marked reduction in hematocrit (41 ± 4 to 28 ± 5%, p < 0.0001) and platelet count (259,000 ± 57,600/ml to 145,900 ± 46,000/ml, p < 0.0001) after bypass. Cardiopulmonary bypass successfully supported all patients during balloon inflation, for an optimal angioplasty result. During balloon inflation, 6 of 8 patients with interpretable electrocardiograms had ST shifts suggestive of ischemia and 1 developed ventricular tachycardia. During balloon inflation, pulse pressure decreased from a mean of 38 ± 15 to 25 ± 15 mm Hg (p < 0.01). It is concluded that cardiopulmonary support provides excellent systemic support but induces cardiac anaerobic metabolism in patients with severe coronary artery disease. Myocardial ischemia when coronary blood flow is interrupted during balloon inflation is still observed despite effective cardiopulmonary support.

Original languageEnglish (US)
Pages (from-to)1344-1348
Number of pages5
JournalThe American Journal of Cardiology
Volume67
Issue number16
DOIs
StatePublished - Jun 15 1991

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Economic Inflation
Coronary Artery Disease
Hemodynamics
Cardiopulmonary Bypass
Angioplasty
Lactic Acid
Anaerobiosis
Blood Pressure
Pressure
Coronary Circulation
Ventricular Tachycardia
Platelet Count
Hematocrit
Pulmonary Artery
Myocardial Ischemia
Pulse
Arterial Pressure
Electrocardiography
Ischemia
Heart Rate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hemodynamic and metabolic effects of venoarterial cardiopulmonary support in coronary artery disease. / Stack, Robert K.; Pavlides, Gregory; Miller, Ronald; Bassett, Joseph; Cieszkowski, John; Gangadharan, Vellapallil; Sakwa, Mark; Clancy, Paul; O'Neill, William W.

In: The American Journal of Cardiology, Vol. 67, No. 16, 15.06.1991, p. 1344-1348.

Research output: Contribution to journalArticle

Stack, RK, Pavlides, G, Miller, R, Bassett, J, Cieszkowski, J, Gangadharan, V, Sakwa, M, Clancy, P & O'Neill, WW 1991, 'Hemodynamic and metabolic effects of venoarterial cardiopulmonary support in coronary artery disease', The American Journal of Cardiology, vol. 67, no. 16, pp. 1344-1348. https://doi.org/10.1016/0002-9149(91)90463-U
Stack, Robert K. ; Pavlides, Gregory ; Miller, Ronald ; Bassett, Joseph ; Cieszkowski, John ; Gangadharan, Vellapallil ; Sakwa, Mark ; Clancy, Paul ; O'Neill, William W. / Hemodynamic and metabolic effects of venoarterial cardiopulmonary support in coronary artery disease. In: The American Journal of Cardiology. 1991 ; Vol. 67, No. 16. pp. 1344-1348.
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abstract = "Coronary angioplasty was performed on 14 high-risk patients supported with venoarterial partial cardiopulmonary bypass. Hemodynamic, metabolic and physiologic parameters were monitored to assess the effect of cardiopulmonary support in conscious patients. Cardiopulmonary support caused a decrease in systolic (45 ± 17 to 27 ± 14 mm Hg, p < 0.001), diastolic (23 ± 12 to 14 ± 8 mm Hg, p < 0.005) and mean (29.7 ± 13.2 to 18 ± 9 mm Hg, p < 0.001) pulmonary artery pressures. Aortic systolic (129 ± 18 to 106 ± 17 mm Hg, p < 0.001), mean (89 ± 19 to 84 ± 19 mm Hg, p < 0.05) and pulse (64 ± 17 to 37 ± 16 mm Hg, p < 0.00001) pressures also decreased. Heart rate and aortic diastolic pressures were unchanged. End-systolic wall stress (122 ± 48 × 103 to 96 ± 44 × 103 dynes/cm2, p < 0.001) and left ventricular end-diastolic diameter (5.7 ± 0.8 to 5.5 ± 0.9 cm, p < 0.05) were reduced during partial cardiopulmonary bypass. After initiation of cardiopulmonary support, normal lactate extraction across the coronary circulation was diminished or converted to lactate production (38 ± 23 to 2 ± 29{\%}, p < 0.005). There was a marked reduction in hematocrit (41 ± 4 to 28 ± 5{\%}, p < 0.0001) and platelet count (259,000 ± 57,600/ml to 145,900 ± 46,000/ml, p < 0.0001) after bypass. Cardiopulmonary bypass successfully supported all patients during balloon inflation, for an optimal angioplasty result. During balloon inflation, 6 of 8 patients with interpretable electrocardiograms had ST shifts suggestive of ischemia and 1 developed ventricular tachycardia. During balloon inflation, pulse pressure decreased from a mean of 38 ± 15 to 25 ± 15 mm Hg (p < 0.01). It is concluded that cardiopulmonary support provides excellent systemic support but induces cardiac anaerobic metabolism in patients with severe coronary artery disease. Myocardial ischemia when coronary blood flow is interrupted during balloon inflation is still observed despite effective cardiopulmonary support.",
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N2 - Coronary angioplasty was performed on 14 high-risk patients supported with venoarterial partial cardiopulmonary bypass. Hemodynamic, metabolic and physiologic parameters were monitored to assess the effect of cardiopulmonary support in conscious patients. Cardiopulmonary support caused a decrease in systolic (45 ± 17 to 27 ± 14 mm Hg, p < 0.001), diastolic (23 ± 12 to 14 ± 8 mm Hg, p < 0.005) and mean (29.7 ± 13.2 to 18 ± 9 mm Hg, p < 0.001) pulmonary artery pressures. Aortic systolic (129 ± 18 to 106 ± 17 mm Hg, p < 0.001), mean (89 ± 19 to 84 ± 19 mm Hg, p < 0.05) and pulse (64 ± 17 to 37 ± 16 mm Hg, p < 0.00001) pressures also decreased. Heart rate and aortic diastolic pressures were unchanged. End-systolic wall stress (122 ± 48 × 103 to 96 ± 44 × 103 dynes/cm2, p < 0.001) and left ventricular end-diastolic diameter (5.7 ± 0.8 to 5.5 ± 0.9 cm, p < 0.05) were reduced during partial cardiopulmonary bypass. After initiation of cardiopulmonary support, normal lactate extraction across the coronary circulation was diminished or converted to lactate production (38 ± 23 to 2 ± 29%, p < 0.005). There was a marked reduction in hematocrit (41 ± 4 to 28 ± 5%, p < 0.0001) and platelet count (259,000 ± 57,600/ml to 145,900 ± 46,000/ml, p < 0.0001) after bypass. Cardiopulmonary bypass successfully supported all patients during balloon inflation, for an optimal angioplasty result. During balloon inflation, 6 of 8 patients with interpretable electrocardiograms had ST shifts suggestive of ischemia and 1 developed ventricular tachycardia. During balloon inflation, pulse pressure decreased from a mean of 38 ± 15 to 25 ± 15 mm Hg (p < 0.01). It is concluded that cardiopulmonary support provides excellent systemic support but induces cardiac anaerobic metabolism in patients with severe coronary artery disease. Myocardial ischemia when coronary blood flow is interrupted during balloon inflation is still observed despite effective cardiopulmonary support.

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