Abstract

Background: Patients with mantle cell lymphoma (MCL) have in general, lower response rates and overall survival (OS) than those with other B-cell non-Hodgkin's lymphomas. The role of hematopoietic stem cell transplantation (HSCT) in MCL is unclear. Hence we decided to study the clinical course of patients who received autologous and allogeneic HSCT for MCL. Methods: Ninety-seven patients, (80 patients-autologous; 17 patients-allogeneic) who received a HSCT for mantle cell lymphoma were included in the study. Results: The complete response rates at day 100 between the two groups were similar (73% vs. 62%). Day-100 mortality was higher in the allogeneic HSCT group (19% vs. 0%) (P<0.01). The estimated 5-year relapse rates, 5-year event-free survival (EFS) and 5-year OS among the allogeneic HSCT patients were 21%, 44% and 49%, respectively, similar to 56%, 39% and 47% in the autologous group. Ten patients received HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone+high-dose methotrexate and cytarabine)±rituximab prior to transplant. There have been no relapses or deaths amongst these patients at a median follow-up of 16 months. Conclusions: Patients treated with allogeneic HSCT had a lower relapse rate, but similar EFS and OS to autologous HSCT. Treatment of MCL with HyperCVAD±rituximab followed by HSCT seems promising.

Original languageEnglish (US)
Pages (from-to)618-624
Number of pages7
JournalAnnals of Oncology
Volume16
Issue number4
DOIs
StatePublished - Apr 1 2005

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Mantle-Cell Lymphoma
Hematopoietic Stem Cell Transplantation
Recurrence
Disease-Free Survival
Survival
Cytarabine
Vincristine
B-Cell Lymphoma
Methotrexate
Non-Hodgkin's Lymphoma
Doxorubicin
Cyclophosphamide
Dexamethasone
Survival Rate
Transplants

Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Autologous hematopoietic stem cell transplantation
  • HyperCVAD
  • Mantle cell lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

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title = "Hematopoietic stem cell transplantation in mantle cell lymphoma",
abstract = "Background: Patients with mantle cell lymphoma (MCL) have in general, lower response rates and overall survival (OS) than those with other B-cell non-Hodgkin's lymphomas. The role of hematopoietic stem cell transplantation (HSCT) in MCL is unclear. Hence we decided to study the clinical course of patients who received autologous and allogeneic HSCT for MCL. Methods: Ninety-seven patients, (80 patients-autologous; 17 patients-allogeneic) who received a HSCT for mantle cell lymphoma were included in the study. Results: The complete response rates at day 100 between the two groups were similar (73{\%} vs. 62{\%}). Day-100 mortality was higher in the allogeneic HSCT group (19{\%} vs. 0{\%}) (P<0.01). The estimated 5-year relapse rates, 5-year event-free survival (EFS) and 5-year OS among the allogeneic HSCT patients were 21{\%}, 44{\%} and 49{\%}, respectively, similar to 56{\%}, 39{\%} and 47{\%} in the autologous group. Ten patients received HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone+high-dose methotrexate and cytarabine)±rituximab prior to transplant. There have been no relapses or deaths amongst these patients at a median follow-up of 16 months. Conclusions: Patients treated with allogeneic HSCT had a lower relapse rate, but similar EFS and OS to autologous HSCT. Treatment of MCL with HyperCVAD±rituximab followed by HSCT seems promising.",
keywords = "Allogeneic hematopoietic stem cell transplantation, Autologous hematopoietic stem cell transplantation, HyperCVAD, Mantle cell lymphoma",
author = "Ganti, {Apar Kishor P} and Bierman, {Philip Jay} and Lynch, {J. C.} and Bociek, {Robert G} and Vose, {Julie Marie} and Armitage, {James Olen}",
year = "2005",
month = "4",
day = "1",
doi = "10.1093/annonc/mdi107",
language = "English (US)",
volume = "16",
pages = "618--624",
journal = "Annals of Oncology",
issn = "0923-7534",
publisher = "Oxford University Press",
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TY - JOUR

T1 - Hematopoietic stem cell transplantation in mantle cell lymphoma

AU - Ganti, Apar Kishor P

AU - Bierman, Philip Jay

AU - Lynch, J. C.

AU - Bociek, Robert G

AU - Vose, Julie Marie

AU - Armitage, James Olen

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Background: Patients with mantle cell lymphoma (MCL) have in general, lower response rates and overall survival (OS) than those with other B-cell non-Hodgkin's lymphomas. The role of hematopoietic stem cell transplantation (HSCT) in MCL is unclear. Hence we decided to study the clinical course of patients who received autologous and allogeneic HSCT for MCL. Methods: Ninety-seven patients, (80 patients-autologous; 17 patients-allogeneic) who received a HSCT for mantle cell lymphoma were included in the study. Results: The complete response rates at day 100 between the two groups were similar (73% vs. 62%). Day-100 mortality was higher in the allogeneic HSCT group (19% vs. 0%) (P<0.01). The estimated 5-year relapse rates, 5-year event-free survival (EFS) and 5-year OS among the allogeneic HSCT patients were 21%, 44% and 49%, respectively, similar to 56%, 39% and 47% in the autologous group. Ten patients received HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone+high-dose methotrexate and cytarabine)±rituximab prior to transplant. There have been no relapses or deaths amongst these patients at a median follow-up of 16 months. Conclusions: Patients treated with allogeneic HSCT had a lower relapse rate, but similar EFS and OS to autologous HSCT. Treatment of MCL with HyperCVAD±rituximab followed by HSCT seems promising.

AB - Background: Patients with mantle cell lymphoma (MCL) have in general, lower response rates and overall survival (OS) than those with other B-cell non-Hodgkin's lymphomas. The role of hematopoietic stem cell transplantation (HSCT) in MCL is unclear. Hence we decided to study the clinical course of patients who received autologous and allogeneic HSCT for MCL. Methods: Ninety-seven patients, (80 patients-autologous; 17 patients-allogeneic) who received a HSCT for mantle cell lymphoma were included in the study. Results: The complete response rates at day 100 between the two groups were similar (73% vs. 62%). Day-100 mortality was higher in the allogeneic HSCT group (19% vs. 0%) (P<0.01). The estimated 5-year relapse rates, 5-year event-free survival (EFS) and 5-year OS among the allogeneic HSCT patients were 21%, 44% and 49%, respectively, similar to 56%, 39% and 47% in the autologous group. Ten patients received HyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone+high-dose methotrexate and cytarabine)±rituximab prior to transplant. There have been no relapses or deaths amongst these patients at a median follow-up of 16 months. Conclusions: Patients treated with allogeneic HSCT had a lower relapse rate, but similar EFS and OS to autologous HSCT. Treatment of MCL with HyperCVAD±rituximab followed by HSCT seems promising.

KW - Allogeneic hematopoietic stem cell transplantation

KW - Autologous hematopoietic stem cell transplantation

KW - HyperCVAD

KW - Mantle cell lymphoma

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U2 - 10.1093/annonc/mdi107

DO - 10.1093/annonc/mdi107

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JF - Annals of Oncology

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