Hematopoietic Cell Transplantation for Hodgkin Disease

Philip Jay Bierman, Auayporn Nademanee

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Patients infected with HIV are more likely to develop Hodgkin disease (HD), and HD has been described following solid organ transplantation. The poor results of conventional-dose salvage therapy for relapsed and refractory HD have led to the use of high-dose therapy (HDT) followed by autologous bone marrow transplantation (BMT) and peripheral blood hematopoietic cell transplantation (PBHCT) for these patients. Radiation is an essential tool in the treatment of HD. The prognosis for children and adolescents with HD is better than for adults and most are cured with primary therapy. Allogeneic HCT may result in a graft-versus-Hodgkin effect similar to the graft-versus-leukemia effect observed after allogeneic HCT for leukemia. Several groups of investigators have explored the use of reduced-intensity conditioning (RIC) allogeneic HCT for HD to exploit potential Graft-versus-Hodgkin disease (GVHL) effects and to reduce transplant-related mortality.

Original languageEnglish (US)
Title of host publicationThomas' Hematopoietic Cell Transplantation
Subtitle of host publicationFifth Edition
PublisherWiley-Blackwell
Pages675-695
Number of pages21
Volume2-2
ISBN (Electronic)9781118416426
ISBN (Print)9781118416006
DOIs
StatePublished - Jan 1 2016

Fingerprint

Cell Transplantation
Hodgkin Disease
Transplants
Leukemia
Salvage Therapy
Autologous Transplantation
Organ Transplantation
Bone Marrow Transplantation
Blood Cells
Therapeutics
Research Personnel
HIV
Radiation
Mortality

Keywords

  • Bone marrow transplantation
  • Graft-versus-host disease
  • Hematopoietic cell transplantation
  • High-dose therapy
  • Hodgkin disease
  • Reduced-intensity conditioning

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bierman, P. J., & Nademanee, A. (2016). Hematopoietic Cell Transplantation for Hodgkin Disease. In Thomas' Hematopoietic Cell Transplantation: Fifth Edition (Vol. 2-2, pp. 675-695). Wiley-Blackwell. https://doi.org/10.1002/9781118416426.ch56

Hematopoietic Cell Transplantation for Hodgkin Disease. / Bierman, Philip Jay; Nademanee, Auayporn.

Thomas' Hematopoietic Cell Transplantation: Fifth Edition. Vol. 2-2 Wiley-Blackwell, 2016. p. 675-695.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bierman, PJ & Nademanee, A 2016, Hematopoietic Cell Transplantation for Hodgkin Disease. in Thomas' Hematopoietic Cell Transplantation: Fifth Edition. vol. 2-2, Wiley-Blackwell, pp. 675-695. https://doi.org/10.1002/9781118416426.ch56
Bierman PJ, Nademanee A. Hematopoietic Cell Transplantation for Hodgkin Disease. In Thomas' Hematopoietic Cell Transplantation: Fifth Edition. Vol. 2-2. Wiley-Blackwell. 2016. p. 675-695 https://doi.org/10.1002/9781118416426.ch56
Bierman, Philip Jay ; Nademanee, Auayporn. / Hematopoietic Cell Transplantation for Hodgkin Disease. Thomas' Hematopoietic Cell Transplantation: Fifth Edition. Vol. 2-2 Wiley-Blackwell, 2016. pp. 675-695
@inbook{c9028b3d93dc4b82be6c6c89a343754a,
title = "Hematopoietic Cell Transplantation for Hodgkin Disease",
abstract = "Patients infected with HIV are more likely to develop Hodgkin disease (HD), and HD has been described following solid organ transplantation. The poor results of conventional-dose salvage therapy for relapsed and refractory HD have led to the use of high-dose therapy (HDT) followed by autologous bone marrow transplantation (BMT) and peripheral blood hematopoietic cell transplantation (PBHCT) for these patients. Radiation is an essential tool in the treatment of HD. The prognosis for children and adolescents with HD is better than for adults and most are cured with primary therapy. Allogeneic HCT may result in a graft-versus-Hodgkin effect similar to the graft-versus-leukemia effect observed after allogeneic HCT for leukemia. Several groups of investigators have explored the use of reduced-intensity conditioning (RIC) allogeneic HCT for HD to exploit potential Graft-versus-Hodgkin disease (GVHL) effects and to reduce transplant-related mortality.",
keywords = "Bone marrow transplantation, Graft-versus-host disease, Hematopoietic cell transplantation, High-dose therapy, Hodgkin disease, Reduced-intensity conditioning",
author = "Bierman, {Philip Jay} and Auayporn Nademanee",
year = "2016",
month = "1",
day = "1",
doi = "10.1002/9781118416426.ch56",
language = "English (US)",
isbn = "9781118416006",
volume = "2-2",
pages = "675--695",
booktitle = "Thomas' Hematopoietic Cell Transplantation",
publisher = "Wiley-Blackwell",
address = "United States",

}

TY - CHAP

T1 - Hematopoietic Cell Transplantation for Hodgkin Disease

AU - Bierman, Philip Jay

AU - Nademanee, Auayporn

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Patients infected with HIV are more likely to develop Hodgkin disease (HD), and HD has been described following solid organ transplantation. The poor results of conventional-dose salvage therapy for relapsed and refractory HD have led to the use of high-dose therapy (HDT) followed by autologous bone marrow transplantation (BMT) and peripheral blood hematopoietic cell transplantation (PBHCT) for these patients. Radiation is an essential tool in the treatment of HD. The prognosis for children and adolescents with HD is better than for adults and most are cured with primary therapy. Allogeneic HCT may result in a graft-versus-Hodgkin effect similar to the graft-versus-leukemia effect observed after allogeneic HCT for leukemia. Several groups of investigators have explored the use of reduced-intensity conditioning (RIC) allogeneic HCT for HD to exploit potential Graft-versus-Hodgkin disease (GVHL) effects and to reduce transplant-related mortality.

AB - Patients infected with HIV are more likely to develop Hodgkin disease (HD), and HD has been described following solid organ transplantation. The poor results of conventional-dose salvage therapy for relapsed and refractory HD have led to the use of high-dose therapy (HDT) followed by autologous bone marrow transplantation (BMT) and peripheral blood hematopoietic cell transplantation (PBHCT) for these patients. Radiation is an essential tool in the treatment of HD. The prognosis for children and adolescents with HD is better than for adults and most are cured with primary therapy. Allogeneic HCT may result in a graft-versus-Hodgkin effect similar to the graft-versus-leukemia effect observed after allogeneic HCT for leukemia. Several groups of investigators have explored the use of reduced-intensity conditioning (RIC) allogeneic HCT for HD to exploit potential Graft-versus-Hodgkin disease (GVHL) effects and to reduce transplant-related mortality.

KW - Bone marrow transplantation

KW - Graft-versus-host disease

KW - Hematopoietic cell transplantation

KW - High-dose therapy

KW - Hodgkin disease

KW - Reduced-intensity conditioning

UR - http://www.scopus.com/inward/record.url?scp=84979900386&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979900386&partnerID=8YFLogxK

U2 - 10.1002/9781118416426.ch56

DO - 10.1002/9781118416426.ch56

M3 - Chapter

AN - SCOPUS:84979900386

SN - 9781118416006

VL - 2-2

SP - 675

EP - 695

BT - Thomas' Hematopoietic Cell Transplantation

PB - Wiley-Blackwell

ER -