Hematogenous metastasis of embryonal rhabdomyosarcoma originating from skeletal muscle in a young dog

Ji Young Yhee, Dae Hyun Kim, Du Na Hwang, Chang Taek Moon, Chi Ho Yu, Hwi Yool Kim, Alan R Doster, Jung Hyang Sur

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An 8-month-old, intact male Golden Retriever with a history of left forelimb lameness for 2 months was presented to the Veterinary Medical Teaching Hospital of Konkuk University (Seoul, Korea). Results of a physical examination revealed a mass in the left axillary region. A thoracic radiography showed an osteolytic lesion in the scapula and the presence of a soft tissue density from the thoracic wall to the scapula. A computerized tomography revealed a mass invading into the scapula, and small nodules in the lung that suggested metastasis. At necropsy, a pale-yellow, irregular, firm, 8 x 10 x 5 cm mass extended from axillary region and destroyed the scapular. In addition, small nodules were noted in the lung. On microscopic examination, the mass consisted of round-to-oval cells, with eccentrically located hyperchromatic nuclei and eosinophilic cytoplasm in fibromyxoid stroma. Tumor cells were observed in blood vessels in the primary mass. Tumor cells strongly expressed vimentin, desmin, and myoglobin. In phosphotungstic acid-hematoxylin staining, cross-striations were detected in rhabdomyoblasts. In periodic acid-Schiff reaction, only a few cells were detected. The diagnosis was primary rhabdomyosarcoma of the appendicular muscle of a young dog. The tumor presumably originated in the skeletal muscle of the limb, invaded into the adjacent scapular bone, and metastasized to the lung.

Original languageEnglish (US)
Pages (from-to)243-246
Number of pages4
JournalJournal of Veterinary Diagnostic Investigation
Volume20
Issue number2
DOIs
StatePublished - Mar 1 2008

Fingerprint

Embryonal Rhabdomyosarcoma
metastasis
Scapula
skeletal muscle
Skeletal Muscle
scapula
Dogs
Neoplasm Metastasis
dogs
Lung
lungs
chest
Thoracic Radiography
Periodic Acid-Schiff Reaction
Phosphotungstic Acid
Neoplasms
Desmin
Forelimb
Rhabdomyosarcoma
Myoglobin

Keywords

  • Dogs
  • Hematogenous metastasis
  • Rhabdomyosarcoma
  • Striated muscle

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Hematogenous metastasis of embryonal rhabdomyosarcoma originating from skeletal muscle in a young dog. / Yhee, Ji Young; Kim, Dae Hyun; Hwang, Du Na; Moon, Chang Taek; Yu, Chi Ho; Kim, Hwi Yool; Doster, Alan R; Sur, Jung Hyang.

In: Journal of Veterinary Diagnostic Investigation, Vol. 20, No. 2, 01.03.2008, p. 243-246.

Research output: Contribution to journalArticle

Yhee, Ji Young ; Kim, Dae Hyun ; Hwang, Du Na ; Moon, Chang Taek ; Yu, Chi Ho ; Kim, Hwi Yool ; Doster, Alan R ; Sur, Jung Hyang. / Hematogenous metastasis of embryonal rhabdomyosarcoma originating from skeletal muscle in a young dog. In: Journal of Veterinary Diagnostic Investigation. 2008 ; Vol. 20, No. 2. pp. 243-246.
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