Abstract
An 8-month-old, intact male Golden Retriever with a history of left forelimb lameness for 2 months was presented to the Veterinary Medical Teaching Hospital of Konkuk University (Seoul, Korea). Results of a physical examination revealed a mass in the left axillary region. A thoracic radiography showed an osteolytic lesion in the scapula and the presence of a soft tissue density from the thoracic wall to the scapula. A computerized tomography revealed a mass invading into the scapula, and small nodules in the lung that suggested metastasis. At necropsy, a pale-yellow, irregular, firm, 8 x 10 x 5 cm mass extended from axillary region and destroyed the scapular. In addition, small nodules were noted in the lung. On microscopic examination, the mass consisted of round-to-oval cells, with eccentrically located hyperchromatic nuclei and eosinophilic cytoplasm in fibromyxoid stroma. Tumor cells were observed in blood vessels in the primary mass. Tumor cells strongly expressed vimentin, desmin, and myoglobin. In phosphotungstic acid-hematoxylin staining, cross-striations were detected in rhabdomyoblasts. In periodic acid-Schiff reaction, only a few cells were detected. The diagnosis was primary rhabdomyosarcoma of the appendicular muscle of a young dog. The tumor presumably originated in the skeletal muscle of the limb, invaded into the adjacent scapular bone, and metastasized to the lung.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 243-246 |
| Number of pages | 4 |
| Journal | Journal of Veterinary Diagnostic Investigation |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2008 |
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Keywords
- Dogs
- Hematogenous metastasis
- Rhabdomyosarcoma
- Striated muscle
ASJC Scopus subject areas
- veterinary(all)
Cite this
Hematogenous metastasis of embryonal rhabdomyosarcoma originating from skeletal muscle in a young dog. / Yhee, Ji Young; Kim, Dae Hyun; Hwang, Du Na; Moon, Chang Taek; Yu, Chi Ho; Kim, Hwi Yool; Doster, Alan R; Sur, Jung Hyang.
In: Journal of Veterinary Diagnostic Investigation, Vol. 20, No. 2, 01.03.2008, p. 243-246.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hematogenous metastasis of embryonal rhabdomyosarcoma originating from skeletal muscle in a young dog
AU - Yhee, Ji Young
AU - Kim, Dae Hyun
AU - Hwang, Du Na
AU - Moon, Chang Taek
AU - Yu, Chi Ho
AU - Kim, Hwi Yool
AU - Doster, Alan R
AU - Sur, Jung Hyang
PY - 2008/3/1
Y1 - 2008/3/1
N2 - An 8-month-old, intact male Golden Retriever with a history of left forelimb lameness for 2 months was presented to the Veterinary Medical Teaching Hospital of Konkuk University (Seoul, Korea). Results of a physical examination revealed a mass in the left axillary region. A thoracic radiography showed an osteolytic lesion in the scapula and the presence of a soft tissue density from the thoracic wall to the scapula. A computerized tomography revealed a mass invading into the scapula, and small nodules in the lung that suggested metastasis. At necropsy, a pale-yellow, irregular, firm, 8 x 10 x 5 cm mass extended from axillary region and destroyed the scapular. In addition, small nodules were noted in the lung. On microscopic examination, the mass consisted of round-to-oval cells, with eccentrically located hyperchromatic nuclei and eosinophilic cytoplasm in fibromyxoid stroma. Tumor cells were observed in blood vessels in the primary mass. Tumor cells strongly expressed vimentin, desmin, and myoglobin. In phosphotungstic acid-hematoxylin staining, cross-striations were detected in rhabdomyoblasts. In periodic acid-Schiff reaction, only a few cells were detected. The diagnosis was primary rhabdomyosarcoma of the appendicular muscle of a young dog. The tumor presumably originated in the skeletal muscle of the limb, invaded into the adjacent scapular bone, and metastasized to the lung.
AB - An 8-month-old, intact male Golden Retriever with a history of left forelimb lameness for 2 months was presented to the Veterinary Medical Teaching Hospital of Konkuk University (Seoul, Korea). Results of a physical examination revealed a mass in the left axillary region. A thoracic radiography showed an osteolytic lesion in the scapula and the presence of a soft tissue density from the thoracic wall to the scapula. A computerized tomography revealed a mass invading into the scapula, and small nodules in the lung that suggested metastasis. At necropsy, a pale-yellow, irregular, firm, 8 x 10 x 5 cm mass extended from axillary region and destroyed the scapular. In addition, small nodules were noted in the lung. On microscopic examination, the mass consisted of round-to-oval cells, with eccentrically located hyperchromatic nuclei and eosinophilic cytoplasm in fibromyxoid stroma. Tumor cells were observed in blood vessels in the primary mass. Tumor cells strongly expressed vimentin, desmin, and myoglobin. In phosphotungstic acid-hematoxylin staining, cross-striations were detected in rhabdomyoblasts. In periodic acid-Schiff reaction, only a few cells were detected. The diagnosis was primary rhabdomyosarcoma of the appendicular muscle of a young dog. The tumor presumably originated in the skeletal muscle of the limb, invaded into the adjacent scapular bone, and metastasized to the lung.
KW - Dogs
KW - Hematogenous metastasis
KW - Rhabdomyosarcoma
KW - Striated muscle
UR - http://www.scopus.com/inward/record.url?scp=45849116959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45849116959&partnerID=8YFLogxK
U2 - 10.1177/104063870802000219
DO - 10.1177/104063870802000219
M3 - Article
VL - 20
SP - 243
EP - 246
JO - Journal of Veterinary Diagnostic Investigation
JF - Journal of Veterinary Diagnostic Investigation
SN - 1040-6387
IS - 2
ER -