Heart failure and carotid body chemoreception

Harold D. Schultz, Noah J. Marcus

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations

Abstract

There is substantial evidence to implicate a role of the carotid body (CB) chemoreflex in sympathetic and breathing dysregulation in several cardio-respiratory diseases, drawing renewed interest in its potential implications for clinical treatment and management. Evidence from both chronic heat failure (CHF) patients and animal models indicates that the CB chemoreflex is enhanced in CHF and contributes to the tonic elevation in sympathetic nerve activity (SNA) and periodic breathing associated with the disease. Although this maladaptive change likely derives from altered function at all levels of the reflex arc, a change in afferent function of the CB is likely to be a main driving force. This review will focus on recent advances in our understanding of the physiological mechanisms that alter CB function in CHF and their potential translational impact on treatment of CHF.

Original languageEnglish (US)
Title of host publicationArterial Chemoreception
Subtitle of host publicationFrom Molecules to Systems
EditorsColin A. Nurse, Chris Peers, Constancio Gonzalez, Nanduri R. Prabhakar
Pages387-395
Number of pages9
DOIs
Publication statusPublished - Dec 7 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume758
ISSN (Print)0065-2598

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Keywords

  • Blood flow
  • Cardiovascular disease
  • Chemoreflex
  • Exercise
  • Kruppel like factor
  • Sleep apnea
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Schultz, H. D., & Marcus, N. J. (2012). Heart failure and carotid body chemoreception. In C. A. Nurse, C. Peers, C. Gonzalez, & N. R. Prabhakar (Eds.), Arterial Chemoreception: From Molecules to Systems (pp. 387-395). (Advances in Experimental Medicine and Biology; Vol. 758). https://doi.org/10.1007/978-94-007-4584-1-52