Health-related quality of life and depression in patients with chronic hepatitis C

Juan Fernando Gallegos-Orozco, Ana Paula Fuentes, Juan Gerardo Argueta, Christian Pérez-Pruna, Carlos Hinojosa-Becerril, Ma Sara Sixtos-Alonso, Socorro Cruz-Castellanos, Gabriela Gutiérrez-Reyes, Marco Antonio Olivera-Martínez, Ma Concepción Gutiérrez-Ruiz, David Kershenobich

Research output: Contribution to journalArticle

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Abstract

Background. Hepatitis C is a major cause of liver disease worldwide. It has been associated with decreased health-related quality of life (HRQL) and psychiatric symptoms. Our aim was to assess HRQL, depression, and illness understanding in patients with chronic hepatitis C without previous interferon therapy. Methods. Consecutive patients attending a referral center were enrolled. HRQL was measured using SF-36 questionnaire, depression with Zung self-rating depression scale, and illness understanding with self-applied knowledge test. Results. Of 157 patients enrolled, 112 were female (71%) and 45 male (29%). Ninety-seven patients (61.8%) had cirrhosis. HRQL was significantly decreased in chronic hepatitis C patients compared to historical normal controls in all eight domains of the SF-36 (p < 0.001). In hepatitis C cirrhotic patients, HRQL was significantly lower among Child-Pugh class B and C subjects in domains reflecting physical health (p <0.05). Ninety-two patients (58.6%) had depression that resulted in lower HRQL when compared to nondepressed patients (p <0.05). One hundred fourteen patients (72.6%) had poor illness understanding of hepatitis C. These subjects had significantly lower HRQL scores in six of eight SF-36 domains when compared to patients with better understanding of the disease (p <0.05). Conclusions. Chronic hepatitis C patients attending a tertiary-referral center had significant decrease in HRQL associated with depression (58.6%) and poor illness understanding (72.6%). Educational programs and their impact on HRQL need to be addressed in detail, particularly for the pre-treatment scenario.

Original languageEnglish (US)
Pages (from-to)124-129
Number of pages6
JournalArchives of Medical Research
Volume34
Issue number2
DOIs
StatePublished - Jan 1 2003

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Chronic Hepatitis C
Quality of Life
Hepatitis C
Tertiary Care Centers
Interferons
Psychiatry
Liver Diseases
Fibrosis
Referral and Consultation

Keywords

  • Chronic hepatitis C
  • Cirrhosis
  • Depression
  • Health-related quality of life
  • SF-36 questionnaire
  • Zung self-rating depression scale

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gallegos-Orozco, J. F., Fuentes, A. P., Argueta, J. G., Pérez-Pruna, C., Hinojosa-Becerril, C., Sixtos-Alonso, M. S., ... Kershenobich, D. (2003). Health-related quality of life and depression in patients with chronic hepatitis C. Archives of Medical Research, 34(2), 124-129. https://doi.org/10.1016/S0188-4409(03)00003-1

Health-related quality of life and depression in patients with chronic hepatitis C. / Gallegos-Orozco, Juan Fernando; Fuentes, Ana Paula; Argueta, Juan Gerardo; Pérez-Pruna, Christian; Hinojosa-Becerril, Carlos; Sixtos-Alonso, Ma Sara; Cruz-Castellanos, Socorro; Gutiérrez-Reyes, Gabriela; Olivera-Martínez, Marco Antonio; Gutiérrez-Ruiz, Ma Concepción; Kershenobich, David.

In: Archives of Medical Research, Vol. 34, No. 2, 01.01.2003, p. 124-129.

Research output: Contribution to journalArticle

Gallegos-Orozco, JF, Fuentes, AP, Argueta, JG, Pérez-Pruna, C, Hinojosa-Becerril, C, Sixtos-Alonso, MS, Cruz-Castellanos, S, Gutiérrez-Reyes, G, Olivera-Martínez, MA, Gutiérrez-Ruiz, MC & Kershenobich, D 2003, 'Health-related quality of life and depression in patients with chronic hepatitis C', Archives of Medical Research, vol. 34, no. 2, pp. 124-129. https://doi.org/10.1016/S0188-4409(03)00003-1
Gallegos-Orozco JF, Fuentes AP, Argueta JG, Pérez-Pruna C, Hinojosa-Becerril C, Sixtos-Alonso MS et al. Health-related quality of life and depression in patients with chronic hepatitis C. Archives of Medical Research. 2003 Jan 1;34(2):124-129. https://doi.org/10.1016/S0188-4409(03)00003-1
Gallegos-Orozco, Juan Fernando ; Fuentes, Ana Paula ; Argueta, Juan Gerardo ; Pérez-Pruna, Christian ; Hinojosa-Becerril, Carlos ; Sixtos-Alonso, Ma Sara ; Cruz-Castellanos, Socorro ; Gutiérrez-Reyes, Gabriela ; Olivera-Martínez, Marco Antonio ; Gutiérrez-Ruiz, Ma Concepción ; Kershenobich, David. / Health-related quality of life and depression in patients with chronic hepatitis C. In: Archives of Medical Research. 2003 ; Vol. 34, No. 2. pp. 124-129.
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AU - Gallegos-Orozco, Juan Fernando

AU - Fuentes, Ana Paula

AU - Argueta, Juan Gerardo

AU - Pérez-Pruna, Christian

AU - Hinojosa-Becerril, Carlos

AU - Sixtos-Alonso, Ma Sara

AU - Cruz-Castellanos, Socorro

AU - Gutiérrez-Reyes, Gabriela

AU - Olivera-Martínez, Marco Antonio

AU - Gutiérrez-Ruiz, Ma Concepción

AU - Kershenobich, David

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N2 - Background. Hepatitis C is a major cause of liver disease worldwide. It has been associated with decreased health-related quality of life (HRQL) and psychiatric symptoms. Our aim was to assess HRQL, depression, and illness understanding in patients with chronic hepatitis C without previous interferon therapy. Methods. Consecutive patients attending a referral center were enrolled. HRQL was measured using SF-36 questionnaire, depression with Zung self-rating depression scale, and illness understanding with self-applied knowledge test. Results. Of 157 patients enrolled, 112 were female (71%) and 45 male (29%). Ninety-seven patients (61.8%) had cirrhosis. HRQL was significantly decreased in chronic hepatitis C patients compared to historical normal controls in all eight domains of the SF-36 (p < 0.001). In hepatitis C cirrhotic patients, HRQL was significantly lower among Child-Pugh class B and C subjects in domains reflecting physical health (p <0.05). Ninety-two patients (58.6%) had depression that resulted in lower HRQL when compared to nondepressed patients (p <0.05). One hundred fourteen patients (72.6%) had poor illness understanding of hepatitis C. These subjects had significantly lower HRQL scores in six of eight SF-36 domains when compared to patients with better understanding of the disease (p <0.05). Conclusions. Chronic hepatitis C patients attending a tertiary-referral center had significant decrease in HRQL associated with depression (58.6%) and poor illness understanding (72.6%). Educational programs and their impact on HRQL need to be addressed in detail, particularly for the pre-treatment scenario.

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KW - Zung self-rating depression scale

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