Head and Neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual

William Michael Lydiatt, Snehal G. Patel, Brian O'Sullivan, Margaret S. Brandwein, John A. Ridge, Jocelyn C. Migliacci, Ashley M. Loomis, Jatin P. Shah

Research output: Contribution to journalArticle

269 Citations (Scopus)

Abstract

Answer questions and earn CME/CNE. The recently released eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual, Head and Neck Section, introduces significant modifications from the prior seventh edition. This article details several of the most significant modifications, and the rationale for the revisions, to alert the reader to evolution of the field. The most significant update creates a separate staging algorithm for high-risk human papillomavirus-associated cancer of the oropharynx, distinguishing it from oropharyngeal cancer with other causes. Other modifications include: the reorganizing of skin cancer (other than melanoma and Merkel cell carcinoma) from a general chapter for the entire body to a head and neck-specific cutaneous malignancies chapter; division of cancer of the pharynx into 3 separate chapters; changes to the tumor (T) categories for oral cavity, skin, and nasopharynx; and the addition of extranodal cancer extension to lymph node category (N) in all but the viral-related cancers and mucosal melanoma. The Head and Neck Task Force worked with colleagues around the world to derive a staging system that reflects ongoing changes in head and neck oncology; it remains user friendly and consistent with the traditional tumor, lymph node, metastasis (TNM) staging paradigm. CA Cancer J Clin 2017;67:122–137.

Original languageEnglish (US)
Pages (from-to)122-137
Number of pages16
JournalCA Cancer Journal for Clinicians
Volume67
Issue number2
DOIs
StatePublished - Mar 1 2017

Fingerprint

Neoplasm Staging
Neck
Head
Oropharyngeal Neoplasms
Neoplasms
Melanoma
Lymph Nodes
Pharyngeal Neoplasms
Merkel Cell Carcinoma
Skin
Nasopharynx
Skin Neoplasms
Advisory Committees
Head and Neck Neoplasms
Mouth
Neoplasm Metastasis

Keywords

  • American Joint Committee on Cancer (AJCC)
  • depth of invasion
  • extranodal extension
  • head and neck cancer
  • human papillomavirus (HPV)
  • human papillomavirus-associated cancer
  • oropharynx
  • prognosis
  • staging

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Lydiatt, W. M., Patel, S. G., O'Sullivan, B., Brandwein, M. S., Ridge, J. A., Migliacci, J. C., ... Shah, J. P. (2017). Head and Neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer Journal for Clinicians, 67(2), 122-137. https://doi.org/10.3322/caac.21389

Head and Neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual. / Lydiatt, William Michael; Patel, Snehal G.; O'Sullivan, Brian; Brandwein, Margaret S.; Ridge, John A.; Migliacci, Jocelyn C.; Loomis, Ashley M.; Shah, Jatin P.

In: CA Cancer Journal for Clinicians, Vol. 67, No. 2, 01.03.2017, p. 122-137.

Research output: Contribution to journalArticle

Lydiatt, WM, Patel, SG, O'Sullivan, B, Brandwein, MS, Ridge, JA, Migliacci, JC, Loomis, AM & Shah, JP 2017, 'Head and Neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual', CA Cancer Journal for Clinicians, vol. 67, no. 2, pp. 122-137. https://doi.org/10.3322/caac.21389
Lydiatt, William Michael ; Patel, Snehal G. ; O'Sullivan, Brian ; Brandwein, Margaret S. ; Ridge, John A. ; Migliacci, Jocelyn C. ; Loomis, Ashley M. ; Shah, Jatin P. / Head and Neck cancers—major changes in the American Joint Committee on cancer eighth edition cancer staging manual. In: CA Cancer Journal for Clinicians. 2017 ; Vol. 67, No. 2. pp. 122-137.
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