Hantavirus pulmonary syndrome in the americas: The early years

A. S. Khan, P. T. Kitsutani, A. L. Corneli

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The initial recognition of hantavirus pulmonary syndrome (HPS) as a new disease associated with a cluster of acute respiratory deaths among American Indians in the southwestern United States in 1993 bears little resemblance to the current understanding of this syndrome. HPS is now recognized as a zoonotic disease that has been endemic throughout the Americas for at least 40 years and that is closely linked to population densities and virus dynamics among a specific subfamily of rodents. The classic disease description has also been markedly broadened to include a spectrum of illness that ranges from asymptomatic infection to fulminate cardiorespiratory failure. Clinical variants with hemorrhagic or prominent renal manifestations have also been recognized. Prevention efforts have been targeted at minimizing peri-domestic contact with rodents and their excreta and improving clinical recognition of infection. This paper describes the pathogenesis underlying the profound cardiorespiratory compromise, person-to-person transmission reported in South America, and viable treatment modalities.

Original languageEnglish (US)
Pages (from-to)313-322
Number of pages10
JournalSeminars in Respiratory and Critical Care Medicine
Volume21
Issue number4
DOIs
StatePublished - Jan 1 2000

Fingerprint

Hantavirus Pulmonary Syndrome
Rodentia
Southwestern United States
Asymptomatic Infections
North American Indians
South America
Zoonoses
Population Density
Viruses
Kidney
Infection
Therapeutics

Keywords

  • Epidemiology
  • Hantavirus pulmonary syndrome
  • Sin Nombre virus
  • Transmission

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Hantavirus pulmonary syndrome in the americas : The early years. / Khan, A. S.; Kitsutani, P. T.; Corneli, A. L.

In: Seminars in Respiratory and Critical Care Medicine, Vol. 21, No. 4, 01.01.2000, p. 313-322.

Research output: Contribution to journalReview article

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