Hand Motor Actions of Children With Cerebral Palsy Are Associated With Abnormal Sensorimotor Cortical Oscillations

Rashelle M. Hoffman, Tony W. Wilson, Max J. Kurz

Research output: Contribution to journalArticle

Abstract

Background. The neuroimaging literature on cerebral palsy (CP) has predominantly focused on identifying the structural aberrations (eg, fiber track integrity), with very few studies examining neural activity within the key networks that serve the production of hand movements. Objective. We aimed to start to fill this knowledge gap by using magnetoencephalographic brain imaging to quantify the temporal dynamics of the sensorimotor oscillations during a hand motor action. Methods: Children with CP (n = 12; MACS [Manual Abilities Classification System] levels I-III) and typically developing (TD) children (n = 26) performed an arrow-based version of the Eriksen flanker task where a button press was performed with either the second or third digit of the right hand depending on the arrow’s direction. Results: Overall, the children with CP were less accurate and had slower reaction times compared with the TD children. These behavioral differences were closely linked with aberrant sensorimotor cortical oscillations seen in the children with CP. Compared with the TD children, the children with CP had a weaker gamma (68-82 Hz) response during motor execution and a weaker post-movement beta rebound (PMBR; 14-26 Hz) response on movement termination. Moreover, we observed a significant correlation between the amplitude of the gamma and PMBR with reaction time, with weaker gamma and PMBR responses being linked with slower reaction times. Conclusions: Overall, these results suggest that aberrations in motor-related gamma and beta cortical oscillations are associated with the impaired hand motor actions seen in children with CP.

Original languageEnglish (US)
Pages (from-to)1018-1028
Number of pages11
JournalNeurorehabilitation and Neural Repair
Volume33
Issue number12
DOIs
StatePublished - Dec 1 2019

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Cerebral Palsy
Hand
Neuroimaging

Keywords

  • MEG
  • finger
  • magnetoencephalography
  • motor control
  • upper extremity

ASJC Scopus subject areas

  • Rehabilitation
  • Neurology
  • Clinical Neurology

Cite this

Hand Motor Actions of Children With Cerebral Palsy Are Associated With Abnormal Sensorimotor Cortical Oscillations. / Hoffman, Rashelle M.; Wilson, Tony W.; Kurz, Max J.

In: Neurorehabilitation and Neural Repair, Vol. 33, No. 12, 01.12.2019, p. 1018-1028.

Research output: Contribution to journalArticle

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